Literature DB >> 10737184

Alpha-glucosidase inhibitors from clove (Syzgium aromaticum).

M Toda1, J Kawabata, T Kasai.   

Abstract

The ellagitannins, casuarictin and eugeniin, were isolated as rat intestinal maltase inhibitors from methanol extracts of clove (Syzgium aromaticum). Eugeniin showed inhibitory activity with an IC50 value of 10(-3) M. A structure-activity relationship study among the isolates and their related compound, penta-O-galloyl-beta-D-glucose, indicates that an increasing number of galloyl units in the molecule might lead to an increase in the inhibitory activity. Eugeniin also inhibited maltase activity toward the human intestinal epithelial cell line, Caco-2.

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Year:  2000        PMID： 10737184     DOI： 10.1271/bbb.64.294

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  9 in total

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2.  Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study.

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Review 3.  Structural features and biological properties of ellagitannins in some plant families of the order Myrtales.

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4.  Anti-hyperglycemic effect of chebulagic acid from the fruits of Terminalia chebula Retz.

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5.  Hypoglycemic Effects of Three Medicinal Plants in Experimental Diabetes: Inhibition of Rat Intestinal α-glucosidase and Enhanced Pancreatic Insulin and Cardiac Glut-4 mRNAs Expression.

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7.  Characterization of Maltase and Sucrase Inhibitory Constituents from Rhodiola crenulata.

Authors:  Wen-Tai Li; Yu-Hsuan Chuang; Jung-Feng Hsieh
Journal:  Foods       Date:  2019-11-02

8.  Inhibitory properties of aqueous ethanol extracts of propolis on alpha-glucosidase.

Authors:  Hongcheng Zhang; Guangxin Wang; Trust Beta; Jie Dong
Journal:  Evid Based Complement Alternat Med       Date:  2015-02-12       Impact factor: 2.629

9.  Synthesis and Comparative Structure-Activity Study of Carbohydrate-Based Phenolic Compounds as α-Glucosidase Inhibitors and Antioxidants.

Authors:  Shota Machida; Saki Mukai; Rina Kono; Megumi Funato; Hiroaki Saito; Taketo Uchiyama
Journal:  Molecules       Date:  2019-11-27       Impact factor: 4.411
  9 in total

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