Literature DB >> 10734225

Polymyxin B binds to anandamide and inhibits its cytotoxic effect.

Y Wang1, Y Liu, K P Sarker, M Nakashima, T Serizawa, A Kishida, M Akashi, M Nakata, I Kitajima, I Maruyama.   

Abstract

Anandamide (ANA), an endogenous cannabinoid, can be generated by activated macrophages during endotoxin shock and is thought to be a paracrine contributor to hypotension. We discovered that ANA in saline/ethanol solution and in serum was efficiently adsorbed in a polymyxin B (PMB)-immobilized beads column and eluted with ethanol. We confirmed the direct binding of PMB to ANA by using surface plasmon resonance. The adsorption of ANA by PMB may abolish the diverse effects of ANA such as hypotension, immunosuppression, and cytotoxicity, and may suggest a new therapeutic strategy for endotoxin shock.

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Year:  2000        PMID： 10734225     DOI： 10.1016/s0014-5793(00)01313-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  20 in total

1.  Early recovery in hemodynamics after direct hemoperfusion with polymyxin B-immobilized fibers may predict mortality rate in patients with septic shock.

Authors:  Atsuko Kobayashi; Yasushi Iwasaki; Yuichi Kimura; Yoshiaki Kawagoe; Yoshihito Ujike
Journal:  J Anesth       Date:  2010-07-17       Impact factor: 2.078

2.  Direct hemoperfusion with a polymyxin B-immobilized cartridge in intestinal warm ischemia reperfusion.

Authors:  Hiroaki Sato; Kiyohiro Oshima; Kazuhisa Arakawa; Katsumi Kobayashi; Hodaka Yamazaki; Yujin Suto; Izumi Takeyoshi
Journal:  World J Gastroenterol       Date:  2008-09-21       Impact factor: 5.742

3.  Intraoperative direct hemoperfusion with a polymyxin-B immobilized fiber column for treatment of infective endocarditis.

Authors:  Toshinori Totsugawa; Masahiko Kuinose; Hidenori Yoshitaka; Yoshimasa Tsushima; Atsuhisa Ishida; Genta Chikazawa; Keijiro Katayama; Arudo Hiraoka
Journal:  Gen Thorac Cardiovasc Surg       Date:  2011-02-10

Review 4.  Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls.

Authors:  Matthew W Buczynski; Loren H Parsons
Journal:  Br J Pharmacol       Date:  2010-06       Impact factor: 8.739

Review 5.  Endocannabinoids in liver disease.

Authors:  Joseph Tam; Jie Liu; Bani Mukhopadhyay; Resat Cinar; Grzegorz Godlewski; George Kunos
Journal:  Hepatology       Date:  2011-01       Impact factor: 17.425

6.  Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis.

Authors:  Shinji Kohro; Hitoshi Imaizumi; Michiaki Yamakage; Yoshiki Masuda; Akiyoshi Namiki; Yasuhumi Asai; Ikuo Maruyama
Journal:  J Anesth       Date:  2006       Impact factor: 2.078

7.  Hemoperfusion with polymyxin B-immobilized fiber column improves liver function after ischemia-reperfusion injury.

Authors:  Hiroaki Sato; Kiyohiro Oshima; Katsumi Kobayashi; Hodaka Yamazaki; Yujin Suto; Izumi Takeyoshi
Journal:  World J Gastroenterol       Date:  2009-09-28       Impact factor: 5.742

8.  High versus standard-volume haemofiltration in hyperdynamic porcine peritonitis: effects beyond haemodynamics?

Authors:  Roman Sykora; Jiri Chvojka; Ales Krouzecky; Jaroslav Radej; Thomas Karvunidis; Veronika Varnerova; Ivan Novak; Martin Matejovic
Journal:  Intensive Care Med       Date:  2008-10-14       Impact factor: 17.440

9.  Early induction of direct hemoperfusion with a polymyxin-B immobilized column is associated with amelioration of hemodynamic derangement and mortality in patients with septic shock.

Authors:  Shinya Chihara; Yoshiki Masuda; Hiroomi Tatsumi; Kota Nakano; Tomokazu Shimada; Takao Murohashi; Michiaki Yamakage
Journal:  J Artif Organs       Date:  2016-07-28       Impact factor: 1.731

10.  Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation.

Authors:  Tomoharu Shimizu; Kazuyoshi Hanasawa; Koichi Sato; Masahiko Umeki; Nobuhiko Koga; Tatsushi Naganuma; Seiji Sato; Tomonori Shimonishi; Toshiaki Ikeda; Naoto Matsuno; Satoshi Ono; Hitoshi Saitoh; Koshi Satoh; Yoshimasa Otani; Yoshihiro Endo; Yutaka Eguchi; Tohru Tani
Journal:  Langenbecks Arch Surg       Date:  2008-08-07       Impact factor: 3.445
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