Literature DB >> 10734218

Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor.

T Nakahashi1, H Fujimura, C A Altar, J Li, J Kambayashi, N N Tandon, B Sun.   

Abstract

Brain-derived neurotrophic factor (BDNF) is an abundant neurotrophin in brain and peripheral nerves, where it affects neural development, survival and repair after injury. BDNF has been detected in rat and human blood, but the source of circulating BDNF is not established. BDNF messenger and peptide were detected in cultured cells and in the culture medium of human umbilical vein endothelial cells. The expression of BDNF was up-regulated by elevation of intracellular cAMP and down-regulated by Ca(2+) ionophore, bovine brain extract and laminar fluid shear stress. These results suggest that vascular endothelial cells may contribute to circulating BDNF.

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Year:  2000        PMID： 10734218     DOI： 10.1016/s0014-5793(00)01302-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  128 in total

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Journal:  Mol Neurobiol       Date:  2012-06-05       Impact factor: 5.590

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Authors:  Paulo Roberto Correia; Fulvio Alexandre Scorza; Sérgio Gomes da Silva; Aline Pansani; Michelle Toscano-Silva; Antonio Carlos de Almeida; Ricardo Mario Arida
Journal:  Neurosci Bull       Date:  2011-10       Impact factor: 5.203

Review 3.  BDNF function as a potential mediator of bipolar disorder and post-traumatic stress disorder comorbidity.

Authors:  J J Rakofsky; K J Ressler; B W Dunlop
Journal:  Mol Psychiatry       Date:  2011-09-20       Impact factor: 15.992

4.  Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models.

Authors:  Heath D Schmidt; Ronald S Duman
Journal:  Neuropsychopharmacology       Date:  2010-08-04       Impact factor: 7.853

Review 5.  Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects.

Authors:  Kristel Knaepen; Maaike Goekint; Elsa Marie Heyman; Romain Meeusen
Journal:  Sports Med       Date:  2010-09-01       Impact factor: 11.136

6.  Preliminary Associations Between Brain-Derived Neurotrophic Factor, Memory Impairment, Functional Cognition, and Depressive Symptoms Following Severe TBI.

Authors:  Michelle D Failla; Shannon B Juengst; Patricia M Arenth; Amy K Wagner
Journal:  Neurorehabil Neural Repair       Date:  2015-08-13       Impact factor: 3.919

7.  Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia.

Authors:  Chie Yasutake; Kenji Kuroda; Toshio Yanagawa; Takehiko Okamura; Hiroshi Yoneda
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2006-06-16       Impact factor: 5.270

Review 8.  The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

Authors:  Tuo Yang; Yang Sun; Zhengyu Lu; Rehana K Leak; Feng Zhang
Journal:  Ageing Res Rev       Date:  2016-09-28       Impact factor: 10.895

9.  High-Intensity Locomotor Exercise Increases Brain-Derived Neurotrophic Factor in Individuals with Incomplete Spinal Cord Injury.

Authors:  Kristan A Leech; T George Hornby
Journal:  J Neurotrauma       Date:  2017-01-18       Impact factor: 5.269

10.  Luteal serum BDNF and HSP70 levels in women with premenstrual dysphoric disorder.

Authors:  E Oral; H Ozcan; T S Kirkan; S Askin; M Gulec; N Aydin
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2013-03-02       Impact factor: 5.270
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