Literature DB >> 10733525

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling.

C Brisken1, A Heineman, T Chavarria, B Elenbaas, J Tan, S K Dey, J A McMahon, A P McMahon, R A Weinberg.   

Abstract

Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1. Transplantation of mammary epithelia from Wnt-4(-)/(-) mice shows that Wnt-4 has an essential role in side-branching early in pregnancy. PR and Wnt-4 mRNAs colocalize to the luminal compartment of the ductal epithelium. Progesterone induces Wnt-4 in mammary epithelial cells and is required for increased Wnt-4 expression during pregnancy. Thus, Wnt signaling is essential in mediating progesterone function during mammary gland morphogenesis.

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Year:  2000        PMID： 10733525      PMCID： PMC316462     

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  28 in total

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Journal:  Cell       Date:  1992-06-26       Impact factor: 41.582

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Journal:  Methods Enzymol       Date:  1993       Impact factor: 1.600

3.  Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.

Authors:  H Roelink; E Wagenaar; S Lopes da Silva; R Nusse
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

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Authors:  J M Bradbury; P A Edwards; C C Niemeyer; T C Dale
Journal:  Dev Biol       Date:  1995-08       Impact factor: 3.582

5.  RAG-1-deficient mice have no mature B and T lymphocytes.

Authors:  P Mombaerts; J Iacomini; R S Johnson; K Herrup; S Tonegawa; V E Papaioannou
Journal:  Cell       Date:  1992-03-06       Impact factor: 41.582

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Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

7.  Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.

Authors:  A S Tsukamoto; R Grosschedl; R C Guzman; T Parslow; H E Varmus
Journal:  Cell       Date:  1988-11-18       Impact factor: 41.582

8.  Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland.

Authors:  B J Gavin; A P McMahon
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

9.  GROWTH OF MOUSE MAMMARY GLANDS IN VIVO AFTER MONOLAYER CULTURE.

Authors:  C W DANIEL; K B DEOME
Journal:  Science       Date:  1965-08-06       Impact factor: 47.728

10.  Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

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Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205
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  211 in total

Review 1.  Murine mammary epithelial stem cells: discovery, function, and current status.

Authors:  Jane E Visvader; Gilbert H Smith
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-02-01       Impact factor: 10.005

Review 2.  Establishing a framework for the functional mammary gland: from endocrinology to morphology.

Authors:  Russell C Hovey; Josephine F Trott; Barbara K Vonderhaar
Journal:  J Mammary Gland Biol Neoplasia       Date:  2002-01       Impact factor: 2.673

Review 3.  Progesterone receptors in mammary gland development and tumorigenesis.

Authors:  Orla M Conneely; Biserka M Jericevic; John P Lydon
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-04       Impact factor: 2.673

Review 4.  Progesterone regulation of reproductive function through functionally distinct progesterone receptor isoforms.

Authors:  Orla M Conneely; Biserka M Jericevic
Journal:  Rev Endocr Metab Disord       Date:  2002-09       Impact factor: 6.514

Review 5.  Next stop, the twilight zone: hedgehog network regulation of mammary gland development.

Authors:  Michael T Lewis; Jacqueline M Veltmaat
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-04       Impact factor: 2.673

Review 6.  Steroid receptors and cell cycle in normal mammary epithelium.

Authors:  Elizabeth Anderson; Robert B Clarke
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-01       Impact factor: 2.673

Review 7.  Eph and ephrin signaling in mammary gland morphogenesis and cancer.

Authors:  Anne-Catherine Andres; Andrew Ziemiecki
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-10       Impact factor: 2.673

8.  Functional development of the mammary gland: use of expression profiling and trajectory clustering to reveal changes in gene expression during pregnancy, lactation, and involution.

Authors:  Michael C Rudolph; James L McManaman; Larry Hunter; Tzulip Phang; Margaret C Neville
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-07       Impact factor: 2.673

Review 9.  Using gene expression arrays to elucidate transcriptional profiles underlying prolactin function.

Authors:  Sandra Gass; Jessica Harris; Chris Ormandy; Cathrin Brisken
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-07       Impact factor: 2.673

Review 10.  Wnt signaling in mammary glands: plastic cell fates and combinatorial signaling.

Authors:  Caroline M Alexander; Shruti Goel; Saja A Fakhraldeen; Soyoung Kim
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-10-01       Impact factor: 10.005
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