L Burd1, R Severud, J Kerbeshian, M G Klug. 1. University of North Dakota School of Medicine and Health Sciences, North Dakota Fetal Alcohol Syndrome Center, Grand Forks, USA. laburd@mail.med.und.nodak.edu
Abstract
AIM: To identify pre- and perinatal risk factors for autism. METHOD: Case control study. We matched names of patients from North Dakota who met DSM criteria for autism, a pervasive developmental disorder, and autistic disorder with their birth certificates. Five matched controls were selected for each case. RESULTS: Univariate analysis of the 78 cases and 390 controls identified seven risk factors. Logistic modeling to control for confounding produced a five variable model. The model parameters were chi 2 = 36.6 and p < 0.001. The five variables in the model were decreased birth weight, low maternal education, later start of prenatal care, and having a previous termination of pregnancy. Increasing father's age was associated with increased risk of autism. CONCLUSION: This methodology may provide an inexpensive method for clinics and public health providers to identify risk factors and to identify maternal characteristics of patients with mental illness and developmental disorders.
AIM: To identify pre- and perinatal risk factors for autism. METHOD: Case control study. We matched names of patients from North Dakota who met DSM criteria for autism, a pervasive developmental disorder, and autistic disorder with their birth certificates. Five matched controls were selected for each case. RESULTS: Univariate analysis of the 78 cases and 390 controls identified seven risk factors. Logistic modeling to control for confounding produced a five variable model. The model parameters were chi 2 = 36.6 and p < 0.001. The five variables in the model were decreased birth weight, low maternal education, later start of prenatal care, and having a previous termination of pregnancy. Increasing father's age was associated with increased risk of autism. CONCLUSION: This methodology may provide an inexpensive method for clinics and public health providers to identify risk factors and to identify maternal characteristics of patients with mental illness and developmental disorders.
Authors: Babu George; M S Razeena Padmam; M K C Nair; M L Leena; Paul Swamidhas Sudhakar Russell Journal: Indian J Pediatr Date: 2014-11-05 Impact factor: 1.967
Authors: Laura A Schieve; Catherine Rice; Owen Devine; Matthew J Maenner; Li-Ching Lee; Robert Fitzgerald; Martha S Wingate; Diana Schendel; Sydney Pettygrove; Kim van Naarden Braun; Maureen Durkin Journal: Ann Epidemiol Date: 2011-10-13 Impact factor: 3.797
Authors: D Q Beversdorf; S E Manning; A Hillier; S L Anderson; R E Nordgren; S E Walters; H N Nagaraja; W C Cooley; S E Gaelic; M L Bauman Journal: J Autism Dev Disord Date: 2005-08