OBJECTIVE: To measure serum levels of müllerian-inhibiting substance (MIS) during the normal menstrual cycle. DESIGN: Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at -80 degrees C until assayed. SETTING: University of Louisville Departments of Obstetrics and Gynecology and Surgery. PATIENT(S): Twenty healthy women 22-35 years of age with normal menstrual cycles. INTERVENTION(S): Blood samples were collected on menstrual cycle day two or three and on the day of LH surge plus one and plus seven or eight. MAIN OUTCOME MEASURE(S): Serum MIS levels were measured by using an enzyme-linked immunosorbent assay. RESULT(S): Serum MIS levels ranged from a low of 1.4 +/- 0.9 ng/mL (mean [+/-SD]) in the early follicular phase, peaked mid-cycle at 1.7 +/- 1.1 ng/mL, and decreased to 1.4 +/- 0.9 ng/mL in the mid-luteal phase of the normal menstrual cycle. CONCLUSION(S): Fluctuations in serum MIS levels during the menstrual cycle suggest that MIS may have a regulatory role in folliculogenesis.
OBJECTIVE: To measure serum levels of müllerian-inhibiting substance (MIS) during the normal menstrual cycle. DESIGN: Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at -80 degrees C until assayed. SETTING: University of Louisville Departments of Obstetrics and Gynecology and Surgery. PATIENT(S): Twenty healthy women 22-35 years of age with normal menstrual cycles. INTERVENTION(S): Blood samples were collected on menstrual cycle day two or three and on the day of LH surge plus one and plus seven or eight. MAIN OUTCOME MEASURE(S): Serum MIS levels were measured by using an enzyme-linked immunosorbent assay. RESULT(S): Serum MIS levels ranged from a low of 1.4 +/- 0.9 ng/mL (mean [+/-SD]) in the early follicular phase, peaked mid-cycle at 1.7 +/- 1.1 ng/mL, and decreased to 1.4 +/- 0.9 ng/mL in the mid-luteal phase of the normal menstrual cycle. CONCLUSION(S): Fluctuations in serum MIS levels during the menstrual cycle suggest that MIS may have a regulatory role in folliculogenesis.
Authors: MaryFran Sowers; Daniel McConnell; Katherine Gast; Huiyong Zheng; Bin Nan; Jenifer D McCarthy; John F Randolph Journal: Fertil Steril Date: 2009-12-06 Impact factor: 7.329
Authors: Susan E Appt; Thomas B Clarkson; Haiying Chen; Michael R Adams; Patricia J Christian; Patricia B Hoyer; Mark E Wilson; Jay R Kaplan Journal: Menopause Date: 2009 May-Jun Impact factor: 2.953
Authors: Joanne F Dorgan; Frank Z Stanczyk; Brian L Egleston; Lisa L Kahle; Christiana M Shaw; Cynthia S Spittle; Andrew K Godwin; Louise A Brinton Journal: J Natl Cancer Inst Date: 2009-10-09 Impact factor: 13.506