Literature DB >> 10730111

Management and morbidity of cellulitis of the leg.

N H Cox1, G B Colver, W D Paterson.   

Abstract

Ascending cellulitis of the leg is a common emergency. An audit was conducted in two district general hospitals to determine how it is managed and the long-term morbidity, and to formulate a treatment strategy. Case notes were reviewed for 92 patients admitted to hospital under adult specialties. Mean duration of inpatient therapy was 10 days. A likely portal of entry was identified in 51/92 cases, of which the commonest were minor injuries and tinea pedis. Pathogens were rarely identified, group G streptococci being the single most frequent organism. Benzylpenicillin was administered in only 43 cases. Long-term morbidity, identified in 8 of 70 patients with over six months' follow-up, included persistent oedema (6) and leg ulceration (2); an additional 19 patients had either suffered previous episodes or experienced a further episode subsequently. Ascending cellulitis of the leg has substantial short-term and long-term morbidity. Important but often neglected therapeutic suggestions are the inclusion of benzylpenicillin in all cases without a contraindication, assessment and treatment of tinea pedis, use of support hosiery, and serological testing for streptococci to confirm the diagnosis in retrospect. The high frequency of recurrent episodes suggests that longer courses of penicillin, or penicillin prophylaxis, might be useful.

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Year:  1998        PMID: 10730111      PMCID: PMC1296982          DOI: 10.1177/014107689809101206

Source DB:  PubMed          Journal:  J R Soc Med        ISSN: 0141-0768            Impact factor:   5.344


  16 in total

1.  Prophylaxis for recurrent cellulitis complicating venous and lymphatic insufficiency.

Authors:  M E Pauszek
Journal:  Indiana Med       Date:  1991-04

2.  QUANTITATIVE ANTISTREPTOKINASE STUDIES IN PATIENTS INFECTED WITH GROUP A HEMOLYTIC STREPTOCOCCI: A COMPARISON WITH SERUM ANTISTREPTOLYSIN AND GAMMA GLOBULIN LEVELS WITH SPECIAL REFERENCE TO THE OCCURRENCE OF RHEUMATIC FEVER.

Authors:  H C Anderson; H G Kunkel; M McCarty
Journal:  J Clin Invest       Date:  1948-07       Impact factor: 14.808

3.  Value of fine-needle aspiration in infectious cellulitis.

Authors:  C Lebre; F Girard-Pipau; J C Roujeau; J Revuz; P Saiag; O Chosidow
Journal:  Arch Dermatol       Date:  1996-07

4.  Value of needle aspiration in bacteriologic diagnosis of cellulitis in adults.

Authors:  P M Newell; C W Norden
Journal:  J Clin Microbiol       Date:  1988-03       Impact factor: 5.948

5.  The value of needle aspiration in the management of cellulitis.

Authors:  T D Epperly
Journal:  J Fam Pract       Date:  1986-10       Impact factor: 0.493

6.  Recurrent erysipelas caused by group B streptococcus organisms.

Authors:  A N Binnick; R B Klein; R D Baughman
Journal:  Arch Dermatol       Date:  1980-07

7.  Group G streptococcal infections on a dermatological ward.

Authors:  C Nohlgård; A Björklind; H Hammar
Journal:  Acta Derm Venereol       Date:  1992       Impact factor: 4.437

8.  The value of bacteriology and serology in the diagnosis of cellulitis and erysipelas.

Authors:  B J Leppard; D V Seal; G Colman; G Hallas
Journal:  Br J Dermatol       Date:  1985-05       Impact factor: 9.302

9.  Microbiologic evaluation of cutaneous cellulitis in adults.

Authors:  E W Hook; T M Hooton; C A Horton; M B Coyle; P G Ramsey; M Turck
Journal:  Arch Intern Med       Date:  1986-02

Review 10.  The role of superantigens in skin disease.

Authors:  D Y Leung; J B Travers; D A Norris
Journal:  J Invest Dermatol       Date:  1995-07       Impact factor: 8.551

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  13 in total

1.  Baseline factors predicting the duration of intravenous antibiotic therapy for cellulitis in an outpatient setting.

Authors:  P J Lillie; D Andrews; K Eaves; T C Darton; A L N Chapman
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-03       Impact factor: 3.267

2.  Do Patients with Cellulitis Need to be Hospitalized? A Systematic Review and Meta-analysis of Mortality Rates of Inpatients with Cellulitis.

Authors:  Craig G Gunderson; Benjamin M Cherry; Ann Fisher
Journal:  J Gen Intern Med       Date:  2018-07-18       Impact factor: 5.128

Review 3.  Bacterial skin infections in the elderly: diagnosis and treatment.

Authors:  Simone Laube; Anne M Farrell
Journal:  Drugs Aging       Date:  2002       Impact factor: 3.923

Review 4.  Interventions for cellulitis and erysipelas.

Authors:  Sally A Kilburn; Peter Featherstone; Bernie Higgins; Richard Brindle
Journal:  Cochrane Database Syst Rev       Date:  2010-06-16

5.  Prophylactic antibiotics for the prevention of cellulitis (erysipelas) of the leg: results of the UK Dermatology Clinical Trials Network's PATCH II trial.

Authors:  Kim Thomas; Angela Crook; Katharine Foster; James Mason; Joanne Chalmers; John Bourke; Adam Ferguson; Nick Level; Andrew Nunn; Hywel Williams
Journal:  Br J Dermatol       Date:  2011-12-06       Impact factor: 9.302

6.  Safety and efficacy of tinea pedis and onychomycosis treatment in people with diabetes: a systematic review.

Authors:  Lisa Matricciani; Kerwin Talbot; Sara Jones
Journal:  J Foot Ankle Res       Date:  2011-12-04       Impact factor: 2.303

7.  Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg.

Authors:  Kim S Thomas; Neil H Cox; Boki S P Savelyich; Debbie Shipley; Sarah Meredith; Andrew Nunn; Nick Reynolds; Hywel C Williams
Journal:  Trials       Date:  2007-01-26       Impact factor: 2.279

8.  Laser therapy for onychomycosis in patients with diabetes at risk for foot complications: study protocol for a randomized, double-blind, controlled trial (LASER-1).

Authors:  Leonie Nijenhuis-Rosien; Nanne Kleefstra; Maurice J Wolfhagen; Klaas H Groenier; Henk J G Bilo; Gijs W D Landman
Journal:  Trials       Date:  2015-03-22       Impact factor: 2.279

9.  Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials.

Authors:  James M Mason; Kim S Thomas; Angela M Crook; Katharine A Foster; Joanne R Chalmers; Andrew J Nunn; Hywel C Williams
Journal:  PLoS One       Date:  2014-02-14       Impact factor: 3.240

10.  Comparing short to standard duration of antibiotic therapy for patients hospitalized with cellulitis (DANCE): study protocol for a randomized controlled trial.

Authors:  Duncan R Cranendonk; Brent C Opmeer; Jan M Prins; W Joost Wiersinga
Journal:  BMC Infect Dis       Date:  2014-05-05       Impact factor: 3.090

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