Literature DB >> 10729320

Modulation of indoleamine 2,3-dioxygenase by interferon-gamma in human placental chorionic villi.

Y Kudo1, C A Boyd, I L Sargent, C W Redman.   

Abstract

The effect of interferon-gamma on indoleamine 2,3-dioxygenase, a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi. The activity of indoleamine 2,3-dioxygenase was markedly stimulated by interferon-gamma in a time- and concentration-dependent manner. Interferon-alpha and interferon-beta also showed a slight stimulatory effect on indoleamine 2,3-dioxygenase activity. The level of indoleamine 2,3-dioxygenase mRNA expression (determined by reverse transcription-polymerase chain reaction) was also enhanced by interferon-gamma. Interleukin-4 showed a dose-dependent inhibitory effect on interferon-gamma-induced stimulation of indoleamine 2,3-dioxygenase activity and mRNA expression.

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Year:  2000        PMID： 10729320     DOI： 10.1093/molehr/6.4.369

Source DB:  PubMed          Journal:  Mol Hum Reprod        ISSN： 1360-9947            Impact factor:   4.025


  8 in total

1.  The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants.

Authors:  Y Kudo; C A Boyd
Journal:  J Physiol       Date:  2001-03-01       Impact factor: 5.182

2.  Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation.

Authors:  Y Kudo; C A Boyd; I L Sargent; C W Redman
Journal:  J Physiol       Date:  2001-08-15       Impact factor: 5.182

3.  Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment.

Authors:  Jeffrey L Wong; Nataša Obermajer; Kunle Odunsi; Robert P Edwards; Pawel Kalinski
Journal:  Cancer Immunol Res       Date:  2016-01-27       Impact factor: 11.151

4.  Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes.

Authors:  Mark K Santillan; Christopher J Pelham; Pimonrat Ketsawatsomkron; Donna A Santillan; Deborah R Davis; Eric J Devor; Katherine N Gibson-Corley; Sabrina M Scroggins; Justin L Grobe; Baoli Yang; Steven K Hunter; Curt D Sigmund
Journal:  Physiol Rep       Date:  2015-01-19

Review 5.  Current State of Preeclampsia Mouse Models: Approaches, Relevance, and Standardization.

Authors:  Christopher A Waker; Melissa R Kaufman; Thomas L Brown
Journal:  Front Physiol       Date:  2021-07-02       Impact factor: 4.566

6.  Indoleamine 2,3-dioxygenase (IDO) is expressed at feto-placental unit throughout mouse gestation: An immunohistochemical study.

Authors:  Hemmati Shayda; Jeddi-Tehrani Mahmood; Torkabadi Ebrahim; Ghassemi Jamileh; Kazemi Sefat Golnaz Ensieh; Danesh Parivash; Barzegar Yarmohammadi Leila; Akhondi Mohammad Mehdi; Zarnani Amir Hassan
Journal:  J Reprod Infertil       Date:  2009-10

Review 7.  The role of placental indoleamine 2,3-dioxygenase in human pregnancy.

Authors:  Yoshiki Kudo
Journal:  Obstet Gynecol Sci       Date:  2013-07-15

8.  Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration.

Authors:  Shanshan Zong; Chunqing Li; Chengfeng Luo; Xin Zhao; Chunhong Liu; Kai Wang; Wenwen Jia; Mingliang Bai; Minghong Yin; Shihua Bao; Jie Guo; Jiuhong Kang; Tao Duan; Qian Zhou
Journal:  Sci Rep       Date:  2016-01-27       Impact factor: 4.379
  8 in total

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