| Literature DB >> 10728656 |
K H Bang1, Y K Kim, B S Min, M K Na, Y H Rhee, J P Lee, K H Bae.
Abstract
Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.Entities:
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Year: 2000 PMID： 10728656 DOI： 10.1007/bf02976465
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946