Literature DB >> 10728491

Predicting the time needed to achieve steady state if absorption and elimination constants are equal.

J Singer1, L Vereczkey.   

Abstract

A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.

Mesh:

Year:  1999        PMID: 10728491     DOI: 10.1023/a:1020947130038

Source DB:  PubMed          Journal:  J Pharmacokinet Biopharm        ISSN: 0090-466X


  3 in total

1.  Rapid compartment- and model-independent estimation of times required to attain various fractions of steady-state plasma level during multiple dosing of drugs obeying superposition principle and having various absorption or infusion kinetics.

Authors:  W L Chiou
Journal:  J Pharm Sci       Date:  1979-12       Impact factor: 3.534

2.  Accumulation profiles during quasi-uniform multiple dosing regimens.

Authors:  I A Nestorov
Journal:  J Pharmacokinet Biopharm       Date:  1993-08

3.  Compartment- and model-independent linear plateau principle of drugs during a constant-rate absorption or intravenous infusion.

Authors:  W L Chiou
Journal:  J Pharmacokinet Biopharm       Date:  1980-06
  3 in total

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