Literature DB >> 10727124

Electrochemical studies of the interaction of adriamycin to DNA.

H M Zhang1, N Q Li.   

Abstract

An electrochemical investigation of the interaction of adriamycin (DXH) with DNA on a Hg electrode is reported. In weakly acidic media of pH 4.0-7.0, the addition of DNA to DXH solution results in the decrease of redox peak currents. In the presence of DNA, no new peak appears and the standard rate constant k(s) is not significantly changed. The binding of DXH to DNA by electrostatic attraction and intercalation forms a kind of supramolecular complex DXH-DNA, which is electrochemically non-active. The equilibrium constant for the complex is calculated. The decrease in peak current is proportional to DNA concentration and can be used to determine DNA concentration.

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Year:  2000        PMID： 10727124     DOI： 10.1016/s0731-7085(99)00254-x

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  2 in total

1.  1-Amino-4-hydroxy-9,10-anthraquinone - An analogue of anthracycline anticancer drugs, interacts with DNA and induces apoptosis in human MDA-MB-231 breast adinocarcinoma cells: Evaluation of structure-activity relationship using computational, spectroscopic and biochemical studies.

Authors:  Palash Mondal; Sanjay Roy; Gayathri Loganathan; Bitapi Mandal; Dhanasekaran Dharumadurai; Mohammad A Akbarsha; Partha Sarathi Sengupta; Shouvik Chattopadhyay; Partha Sarathi Guin
Journal:  Biochem Biophys Rep       Date:  2015-10-23

2.  Electrochemical, spectroscopic and theoretical monitoring of anthracyclines' interactions with DNA and ascorbic acid by adopting two routes: Cancer cell line studies.

Authors:  Fouzia Perveen; Nasima Arshad; Rumana Qureshi; Jahanzaib Nowsherwan; Aiesha Sultan; Bushra Nosheen; Hummera Rafique
Journal:  PLoS One       Date:  2018-10-29       Impact factor: 3.240
  2 in total

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