Literature DB >> 10726874

A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana.

Y H Kuo1, C H Lin, S Y Hwang, Y C Shen, Y L Lee, L Shyh-Yuan.   

Abstract

Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone-A (1). Its structure was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.

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Year:  2000        PMID： 10726874     DOI： 10.1248/cpb.48.440

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  5 in total

1.  Acyl flavonoids, biflavones, and flavonoids from Cephalotaxus harringtonia var. nana.

Authors:  Noriko Komoto; Takahisa Nakane; Sachiko Matsumoto; Shusuke Hashimoto; Osamu Shirota; Setsuko Sekita; Masanori Kuroyanagi
Journal:  J Nat Med       Date:  2015-04-24       Impact factor: 2.343

2.  Antioxidant, antibacterial, cytotoxic, and apoptotic activity of stem bark extracts of Cephalotaxus griffithii Hook. f.

Authors:  Dinesh Singh Moirangthem; Narayan Chandra Talukdar; Naresh Kasoju; Utpal Bora
Journal:  BMC Complement Altern Med       Date:  2012-04-03       Impact factor: 3.659

3.  Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma.

Authors:  Zhen-Nan Ye; Mu-Yuan Yu; Ling-Mei Kong; Wei-Hua Wang; Yuan-Feng Yang; Jie-Qing Liu; Ming-Hua Qiu; Yan Li
Journal:  Nat Prod Bioprospect       Date:  2015-03-29

4.  Cephalotaxus griffithii Hook.f. needle extract induces cell cycle arrest, apoptosis and suppression of hTERT and hTR expression on human breast cancer cells.

Authors:  Dinesh Singh Moirangthem; Surbala Laishram; Jagat Chandra Borah; Mohan Chandra Kalita; Narayan Chandra Talukdar
Journal:  BMC Complement Altern Med       Date:  2014-08-18       Impact factor: 3.659

Review 5.  A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid.

Authors:  Sheng Yu; Hui Yan; Li Zhang; Mingqiu Shan; Peidong Chen; Anwei Ding; Sam Fong Yau Li
Journal:  Molecules       Date:  2017-02-16       Impact factor: 4.411
  5 in total

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