Literature DB >> 10725920

Synapsins as mediators of BDNF-enhanced neurotransmitter release.

J N Jovanovic1, A J Czernik, A A Fienberg, P Greengard, T S Sihra.   

Abstract

We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to inhibit MAP kinase activity, markedly decreased synapsin I phosphorylation and concomitantly reduced neurotransmitter release. The stimulation of glutamate release by BDNF was strongly attenuated in mice lacking synapsin I and/or synapsin II. These results indicate a causal link of synapsin phosphorylation via BDNF, TrkB receptors and MAP kinase with downstream facilitation of neurotransmitter release.

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Year:  2000        PMID： 10725920     DOI： 10.1038/73888

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  196 in total

Review 1.  Neurotrophins: roles in neuronal development and function.

Authors:  E J Huang; L F Reichardt
Journal:  Annu Rev Neurosci       Date:  2001       Impact factor: 12.449

2.  A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.

Authors:  H Ohnishi; S Yamamori; K Ono; K Aoyagi; S Kondo; M Takahashi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

Review 3.  Retrograde signaling at central synapses.

Authors:  H W Tao; M Poo
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

Review 4.  CXC chemokine receptors in the central nervous system: Role in cerebellar neuromodulation and development.

Authors:  Davide Ragozzino
Journal:  J Neurovirol       Date:  2002-12       Impact factor: 2.643

Review 5.  The role of neurotrophins in neurotransmitter release.

Authors:  William J Tyler; Stephen P Perrett; Lucas D Pozzo-Miller
Journal:  Neuroscientist       Date:  2002-12       Impact factor: 7.519

6.  Transcriptional analysis in the brain: trophin-induced hippocampal synaptic plasticity.

Authors:  Janet Alder; Smita Thakker-Varia; Ira B Black
Journal:  Neurochem Res       Date:  2002-10       Impact factor: 3.996

7.  The role of extracellular regulated kinases I/II in late-phase long-term potentiation.

Authors:  Kobi Rosenblum; Marie Futter; Karen Voss; Muriel Erent; Paul A Skehel; Pim French; Louis Obosi; Matt W Jones; Tim V P Bliss
Journal:  J Neurosci       Date:  2002-07-01       Impact factor: 6.167

Review 8.  Anterograde transport of neurotrophic factors: possible therapeutic implications.

Authors:  Matteo Caleo; Maria Cristina Cenni
Journal:  Mol Neurobiol       Date:  2004-04       Impact factor: 5.590

Review 9.  Mapping molecular memory: navigating the cellular pathways of learning.

Authors:  Gavin R Owen; Elisabeth Anne Brenner
Journal:  Cell Mol Neurobiol       Date:  2012-04-10       Impact factor: 5.046

10.  BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression.

Authors:  F Gómez-Pinilla; J R Huie; Z Ying; A R Ferguson; E D Crown; K M Baumbauer; V R Edgerton; J W Grau
Journal:  Neuroscience       Date:  2007-08-23       Impact factor: 3.590
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