Literature DB >> 10725904

Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?

T Meinnel1.   

Abstract

Peptide deformylase is found only in Eubacteria, making it a logical target for discovering new antibacterial agents. Although this protein is absent from animal or fungal cells, evidence supports its existence in eukaryotic protists, including the causative agents of malaria, sleeping sickness, Chagas disease and leishmaniosis. Here, Thierry Meinnel discusses the idea that deformylase inhibitors could be used as very broad-spectrum antibiotics against bacterial infections, as well as parasitic diseases.

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Year:  2000        PMID： 10725904     DOI： 10.1016/s0169-4758(99)01627-0

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  9 in total

1.  Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms.

Authors:  C Giglione; A Serero; M Pierre; B Boisson; T Meinnel
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

2.  Eukaryotic peptide deformylases. Nuclear-encoded and chloroplast-targeted enzymes in Arabidopsis.

Authors:  L M Dirk; M A Williams; R L Houtz
Journal:  Plant Physiol       Date:  2001-09       Impact factor: 8.340

3.  Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.

Authors:  Mona D Lee; Yuhong She; Michael J Soskis; Christopher P Borella; Jeffrey R Gardner; Paula A Hayes; Benzon M Dy; Mark L Heaney; Mark R Philips; William G Bornmann; Francis M Sirotnak; David A Scheinberg
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

4.  Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase.

Authors:  Carlos D Amero; Douglas W Byerly; Craig A McElroy; Amber Simmons; Mark P Foster
Journal:  Biochemistry       Date:  2009-08-18       Impact factor: 3.162

5.  Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapy.

Authors:  Huamei Fu; Claes Dahlgren; Johan Bylund
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

6.  Control of protein life-span by N-terminal methionine excision.

Authors:  Carmela Giglione; Olivier Vallon; Thierry Meinnel
Journal:  EMBO J       Date:  2003-01-02       Impact factor: 11.598

7.  Parasite plastids: maintenance and functions.

Authors:  R J M Iain Wilson; K Rangachari; J W Saldanha; L Rickman; R S Buxton; J F Eccleston
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2003-01-29       Impact factor: 6.237

8.  Ligand and Structure-Based Approaches for the Identification of Peptide Deformylase Inhibitors as Antibacterial Drugs.

Authors:  Jian Gao; Li Liang; Yasheng Zhu; Shengzhi Qiu; Tao Wang; Ling Zhang
Journal:  Int J Mol Sci       Date:  2016-07-15       Impact factor: 5.923

9.  Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation.

Authors:  Noga Naor; Omer Gadot; Michal Meir; Daniel Barkan
Journal:  BMC Microbiol       Date:  2019-10-26       Impact factor: 3.605
  9 in total

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