Literature DB >> 10725755

Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci.

O Kanagawa1, G Xu, A Tevaarwerk, B A Vaupel.   

Abstract

Nonobese diabetic (NOD) mice carrying a segment of chromosome flanking the disrupted IFN-gamma receptor gene from original 129 ES cells are resistant to development of diabetes. However, extended backcrossing of this mouse line to the NOD mouse resulted in a segregation of the IFN-gammaR-deficient genotype from the diabetes-resistant phenotype. These results indicate that the protection of NOD mice from the development of diabetes is not directly linked to the defective IFN-gamma receptor gene but, rather, is influenced by the presence of a diabetes-resistant gene(s) closely linked to the IFN-gammaR loci derived from the 129 mouse strain.

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Year:  2000        PMID： 10725755     DOI： 10.4049/jimmunol.164.7.3919

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  36 in total

1.  Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator.

Authors:  Simone Cenci; Gianluca Toraldo; M Neale Weitzmann; Cristiana Roggia; Yuhao Gao; Wei Ping Qian; Oscar Sierra; Roberto Pacifici
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-15       Impact factor: 11.205

2.  An update on the use of NOD mice to study autoimmune (Type 1) diabetes.

Authors:  Rodolfo José Chaparro; Teresa P Dilorenzo
Journal:  Expert Rev Clin Immunol       Date:  2010-11       Impact factor: 4.473

3.  IFN-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes.

Authors:  Boris Calderon; Anish Suri; Xiaoou O Pan; Jason C Mills; Emil R Unanue
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

4.  Interferon-γ Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.

Authors:  John P Driver; Jeremy J Racine; Cheng Ye; Deanna J Lamont; Brittney N Newby; Caroline M Leeth; Harold D Chapman; Todd M Brusko; Yi-Guang Chen; Clayton E Mathews; David V Serreze
Journal:  Diabetes       Date:  2016-12-05       Impact factor: 9.461

Review 5.  Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.

Authors:  Nick Holmes; Anne Cooke
Journal:  Rev Diabet Stud       Date:  2012-12-28

6.  Islet antigen-specific Th17 cells can induce TNF-α-dependent autoimmune diabetes.

Authors:  Cheng-Rui Li; Erin E Mueller; Linda M Bradley
Journal:  J Immunol       Date:  2014-01-20       Impact factor: 5.422

7.  Substrains of 129 mice are resistant to Yersinia pestis KIM5: implications for interleukin-10-deficient mice.

Authors:  Joshua K Turner; John L Xu; Richard I Tapping
Journal:  Infect Immun       Date:  2008-10-27       Impact factor: 3.441

8.  Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice.

Authors:  David Bending; Hugo De la Peña; Marc Veldhoen; Jenny M Phillips; Catherine Uyttenhove; Brigitta Stockinger; Anne Cooke
Journal:  J Clin Invest       Date:  2009-02-02       Impact factor: 14.808

9.  NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.

Authors:  Edward H Leiter; Peter C Reifsnyder; Racheal Wallace; Renhua Li; Benjamin King; Gary C Churchill
Journal:  Diabetes       Date:  2009-03-31       Impact factor: 9.461

10.  Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency.

Authors:  Xiaopei L Zeng; Anil Nagavalli; Colin-Jamal Smith; James F Howard; Maureen A Su
Journal:  J Immunol       Date:  2013-03-13       Impact factor: 5.422
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