Literature DB >> 10725422

Protective effects of a live attenuated bovine leukaemia virus vaccine with deletion in the R3 and G4 genes.

M Reichert1, G H Cantor, L Willems, R Kettmann.   

Abstract

In this study the protective effects of a live attenuated bovine leukaemia provirus (pBLVDX) with deletion in the R3 and G4 genes were tested. Six out of six sheep appeared to resist challenge with parental BLV344. Two out of three animals transfected with pBLVDX were protected against challenge with bovine leukaemia virus (BLV) from a naturally infected cow. As a model for the protection against infection by members of the human T-lymphotropic virus/BLV group, these data provide evidence that a DNA-based vaccination with an attenuated provirus is able to protect against challenge infections.

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Year:  2000        PMID： 10725422     DOI： 10.1099/0022-1317-81-4-965

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  5 in total

1.  Subcellular localization of the bovine leukemia virus R3 and G4 accessory proteins.

Authors:  Laurent Lefèbvre; Vincenzo Ciminale; Alain Vanderplasschen; Donna D'Agostino; Arsène Burny; Luc Willems; Richard Kettmann
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103

2.  Even attenuated bovine leukemia virus proviruses can be pathogenic in sheep.

Authors:  Arnaud Florins; Nicolas Gillet; Mathieu Boxus; Pierre Kerkhofs; Richard Kettmann; Luc Willems
Journal:  J Virol       Date:  2007-07-11       Impact factor: 5.103

Review 3.  Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV.

Authors:  Sabrina M Rodríguez; Arnaud Florins; Nicolas Gillet; Alix de Brogniez; María Teresa Sánchez-Alcaraz; Mathieu Boxus; Fanny Boulanger; Gerónimo Gutiérrez; Karina Trono; Irene Alvarez; Lucas Vagnoni; Luc Willems
Journal:  Viruses       Date:  2011-07-19       Impact factor: 5.048

Review 4.  Vaccination against δ-retroviruses: the bovine leukemia virus paradigm.

Authors:  Gerónimo Gutiérrez; Sabrina M Rodríguez; Alix de Brogniez; Nicolas Gillet; Ramarao Golime; Arsène Burny; Juan-Pablo Jaworski; Irene Alvarez; Lucas Vagnoni; Karina Trono; Luc Willems
Journal:  Viruses       Date:  2014-06-20       Impact factor: 5.048

Review 5.  Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human.

Authors:  Nicolas Gillet; Arnaud Florins; Mathieu Boxus; Catherine Burteau; Annamaria Nigro; Fabian Vandermeers; Hervé Balon; Amel-Baya Bouzar; Julien Defoiche; Arsène Burny; Michal Reichert; Richard Kettmann; Luc Willems
Journal:  Retrovirology       Date:  2007-03-16       Impact factor: 4.602
  5 in total

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