BACKGROUND: Peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by fatty acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZDs). The TZD troglitazone (TRO) inhibits vascular smooth muscle cell (VSMC) proliferation and migration in vitro and in postinjury intimal hyperplasia. METHODS AND RESULTS: Rat and human VSMCs express mRNA and nuclear receptors for PPARgamma1. Three PPARgamma ligands, the TZDs TRO and rosiglitazone and the prostanoid 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), all inhibited VSMC proliferation and migration. PPARgamma is upregulated in rat neointima at 7 days and 14 days after balloon injury and is also present in early human atheroma and precursor lesions. CONCLUSIONS: Pharmacological activation of PPARgamma expressed in VSMCs inhibits their proliferation and migration, potentially limiting restenosis and atherosclerosis. These receptors are upregulated during vascular injury.
BACKGROUND:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by fatty acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZDs). The TZD troglitazone (TRO) inhibits vascular smooth muscle cell (VSMC) proliferation and migration in vitro and in postinjury intimal hyperplasia. METHODS AND RESULTS:Rat and human VSMCs express mRNA and nuclear receptors for PPARgamma1. Three PPARgamma ligands, the TZDsTRO and rosiglitazone and the prostanoid15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), all inhibited VSMC proliferation and migration. PPARgamma is upregulated in rat neointima at 7 days and 14 days after balloon injury and is also present in early humanatheroma and precursor lesions. CONCLUSIONS: Pharmacological activation of PPARgamma expressed in VSMCs inhibits their proliferation and migration, potentially limiting restenosis and atherosclerosis. These receptors are upregulated during vascular injury.
Authors: Min Ding; Ana Catarina Carrão; Robert J Wagner; Yi Xie; Yu Jin; Eva M Rzucidlo; Jun Yu; Wei Li; George Tellides; John Hwa; Tamar R Aprahamian; Kathleen A Martin Journal: J Mol Cell Cardiol Date: 2011-09-17 Impact factor: 5.000
Authors: Dane Meredith; Manikandan Panchatcharam; Sumitra Miriyala; Yau-Sheng Tsai; Andrew J Morris; Nobuyo Maeda; George A Stouffer; Susan S Smyth Journal: Arterioscler Thromb Vasc Biol Date: 2009-01-29 Impact factor: 8.311
Authors: Andrew C Li; Christoph J Binder; Alejandra Gutierrez; Kathleen K Brown; Christine R Plotkin; Jennifer W Pattison; Annabel F Valledor; Roger A Davis; Timothy M Willson; Joseph L Witztum; Wulf Palinski; Christopher K Glass Journal: J Clin Invest Date: 2004-12 Impact factor: 14.808
Authors: Wiebke Wolfsgruber; Susanne Feil; Sabine Brummer; Oliver Kuppinger; Franz Hofmann; Robert Feil Journal: Proc Natl Acad Sci U S A Date: 2003-11-03 Impact factor: 11.205