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Literature DB >> 10724328

Sarco/endoplasmic reticulum Ca2+-pump isoform SERCA3a is more resistant to superoxide damage than SERCA2b.

Abstract

Endo/sarcoplasmic reticulum (ER) Ca2+-pumps are important for cell survival and communication but they are inactivated by reactive oxygen species (ROS). We have previously reported that the Ca2+-pump isoform SERCA3a is more resistant than SERCA2b to damage by peroxide. Since peroxide and superoxide differ in their redox potentials, we now report the effects of superoxide on the two Ca2+-pump isoforms. We isolated microsomes from HEK293 cells transiently transfected with SERCA2b or SERCA3a cDNA. We exposed these microsomes to superoxide which was generated using xanthine plus xanthine oxidase and catalase to prevent accumulation of peroxide due to superoxide dismutation. Superoxide damaged the Ca2+-transport activity of both isoforms but SERCA3a was damaged at higher concentrations of superoxide and upon longer periods of exposures than was SERCA2b. Thus the SERCA3a isoform is more resistant than SERCA2b to inactivation by both superoxide and peroxide.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2000 PMID： 10724328 DOI： 10.1023/a:1007053802481

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

22 in total

Review 1. Function and organization of the inositol 1,4,5-trisphosphate-sensitive calcium pool.

Authors: D L Gill; T K Ghosh; J Bian; A D Short; R T Waldron; S L Rybak
Journal: Adv Second Messenger Phosphoprotein Res Date: 1992

Review 2. Free radicals and their involvement during long-term myocardial ischemia and reperfusion.

Authors: J M Downey
Journal: Annu Rev Physiol Date: 1990 Impact factor: 19.318

3. cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump.

Authors: S E Burk; J Lytton; D H MacLennan; G E Shull
Journal: J Biol Chem Date: 1989-11-05 Impact factor: 5.157

Review 4. Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores.

Authors: L Missiaen; F Wuytack; L Raeymaekers; H De Smedt; G Droogmans; I Declerck; R Casteels
Journal: Pharmacol Ther Date: 1991 Impact factor: 12.310

5. Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts.

Authors: K D Wu; W S Lee; J Wey; D Bungard; J Lytton
Journal: Am J Physiol Date: 1995-09

6. Peroxide resistance of ER Ca2+ pump in endothelium: implications to coronary artery function.

Authors: A K Grover; S E Samson
Journal: Am J Physiol Date: 1997-10

7. Effect of superoxide radical on Ca2+ pumps of coronary artery.

Authors: A K Grover; S E Samson
Journal: Am J Physiol Date: 1988-09

Review 8. Endogenous antioxidant changes in the myocardium in response to acute and chronic stress conditions.

Authors: P K Singal; A K Dhalla; M Hill; T P Thomas
Journal: Mol Cell Biochem Date: 1993-12-22 Impact factor: 3.396

9. A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells.

Authors: F Wuytack; B Papp; H Verboomen; L Raeymaekers; L Dode; R Bobe; J Enouf; S Bokkala; K S Authi; R Casteels
Journal: J Biol Chem Date: 1994-01-14 Impact factor: 5.157

10. Oxygen free radical-mediated selective endothelial dysfunction in isolated coronary artery.

Authors: K Todoki; E Okabe; T Kiyose; T Sekishita; H Ito
Journal: Am J Physiol Date: 1992-03

14 in total

1. H2O2 mobilizes Ca2+ from agonist- and thapsigargin-sensitive and insensitive intracellular stores and stimulates glutamate secretion in rat hippocampal astrocytes.

Authors: Antonio González; María P Granados; José A Pariente; Ginés M Salido
Journal: Neurochem Res Date: 2006-06-23 Impact factor: 3.996

10. Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.

Authors: E M McElnea; B Quill; N G Docherty; M Irnaten; W F Siah; A F Clark; C J O'Brien; D M Wallace
Journal: Mol Vis Date: 2011-05-05 Impact factor: 2.367

Sarco/endoplasmic reticulum Ca2+-pump isoform SERCA3a is more resistant to superoxide damage than SERCA2b.

Review 1. Function and organization of the inositol 1,4,5-trisphosphate-sensitive calcium pool.

Review 2. Free radicals and their involvement during long-term myocardial ischemia and reperfusion.

3. cDNA cloning, functional expression, and mRNA tissue distribution of a third organellar Ca2+ pump.

Review 4. Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores.

5. Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts.

6. Peroxide resistance of ER Ca2+ pump in endothelium: implications to coronary artery function.

7. Effect of superoxide radical on Ca2+ pumps of coronary artery.

Review 8. Endogenous antioxidant changes in the myocardium in response to acute and chronic stress conditions.

9. A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells.

10. Oxygen free radical-mediated selective endothelial dysfunction in isolated coronary artery.

1. H2O2 mobilizes Ca2+ from agonist- and thapsigargin-sensitive and insensitive intracellular stores and stimulates glutamate secretion in rat hippocampal astrocytes.

Review 2. Redox regulation of store-operated Ca2+ entry.

Review 3. Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels.

4. Ascorbate uptake in pig coronary artery endothelial cells.

5. Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum.

Review 6. Reactive oxygen species: impact on skeletal muscle.

7. CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells.

8. xCT expression reduces the early cell cycle requirement for calcium signaling.

Review 9. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production.

10. Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors.