Literature DB >> 10722522

Toward antiviral strategies that resist viral escape.

D Endy1, J Yin.   

Abstract

We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance.

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Year:  2000        PMID： 10722522      PMCID： PMC89823          DOI： 10.1128/AAC.44.4.1097-1099.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Authors:  T A Hjalt; E G Wagner
Journal:  Nucleic Acids Res       Date:  1995-02-25       Impact factor: 16.971

2.  Virus dynamics and drug therapy.

Authors:  S Bonhoeffer; R M May; G M Shaw; M A Nowak
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3.  Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound.

Authors:  B A Heinz; R R Rueckert; D A Shepard; F J Dutko; M A McKinlay; M Fancher; M G Rossmann; J Badger; T J Smith
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

4.  Ritonavir and saquinavir combination therapy for the treatment of HIV infection.

Authors:  D W Cameron; A J Japour; Y Xu; A Hsu; J Mellors; C Farthing; C Cohen; D Poretz; M Markowitz; S Follansbee; J B Angel; D McMahon; D Ho; V Devanarayan; R Rode; M Salgo; D J Kempf; R Granneman; J M Leonard; E Sun
Journal:  AIDS       Date:  1999-02-04       Impact factor: 4.177

5.  The amino terminal domain of HIV-1 Rev is required for discrimination of the RRE from nonspecific RNA.

Authors:  T J Daly; R C Doten; J R Rusche; M Auer
Journal:  J Mol Biol       Date:  1995-10-20       Impact factor: 5.469

6.  HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.

Authors:  A S Perelson; A U Neumann; M Markowitz; J M Leonard; D D Ho
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7.  Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor.

Authors:  D D Ho; T Toyoshima; H Mo; D J Kempf; D Norbeck; C M Chen; N E Wideburg; S K Burt; J W Erickson; M K Singh
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8.  Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro.

Authors:  B A Larder; P Kellam; S D Kemp
Journal:  Nature       Date:  1993-09-30       Impact factor: 49.962

9.  Implication of RNA structure on antisense oligonucleotide hybridization kinetics.

Authors:  W F Lima; B P Monia; D J Ecker; S M Freier
Journal:  Biochemistry       Date:  1992-12-08       Impact factor: 3.162

10.  Intracellular kinetics of a growing virus: a genetically structured simulation for bacteriophage T7.

Authors:  D Endy; D Kong; J Yin
Journal:  Biotechnol Bioeng       Date:  1997-07-20       Impact factor: 4.530
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  11 in total

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Authors:  Eric L Haseltine; John Yin; James B Rawlings
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5.  Autonomous targeting of infectious superspreaders using engineered transmissible therapies.

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Authors:  Kristen A Stauffer Thompson; John Yin
Journal:  Virol J       Date:  2010-09-29       Impact factor: 4.099

7.  Spatial-Temporal Patterns of Viral Amplification and Interference Initiated by a Single Infected Cell.

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Review 8.  CRM1 Inhibitors for Antiviral Therapy.

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9.  An Intra-Vaginal Zinc Oxide Tetrapod Nanoparticles (ZOTEN) and Genital Herpesvirus Cocktail Can Provide a Novel Platform for Live Virus Vaccine.

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10.  Multiscale modeling of influenza A virus infection supports the development of direct-acting antivirals.

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