| Literature DB >> 10722518 |
M Yuan1, L M Hall, P H Savelkoul, C M Vandenbroucke-Grauls, D M Livermore.
Abstract
Eleven clonally related Klebsiella pneumoniae isolates were examined. These had been isolated at an intensive care unit in Amsterdam in 1994. Their resistance was associated with a conjugative 170-kb plasmid which encoded a novel SHV beta-lactamase designated SHV-13. The SHV-13 enzyme had two substitutions compared with SHV-1: Leu35Gln and Gly238Ala. It hydrolyzed cefotaxime much more rapidly than ceftazidime or aztreonam.Entities:
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Year: 2000 PMID: 10722518 PMCID: PMC89819 DOI: 10.1128/AAC.44.4.1081-1084.2000
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191