Literature DB >> 10720723

Toxicodynamics and long-term toxicity of the recreational drug, 3, 4-methylenedioxymethamphetamine (MDMA, 'Ecstasy').

G A Ricaurte1, U D McCann, Z Szabo, U Scheffel.   

Abstract

The recreational drug, (+/-)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [11C]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [11C]McN-5652 binding, with decreases in [11C]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity.

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Year:  2000        PMID： 10720723     DOI： 10.1016/s0378-4274(99)00216-7

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  19 in total

1.  Does recreational ecstasy use cause long-term cognitive problems?

Authors:  P A Kelly
Journal:  West J Med       Date:  2000-08

2.  In vitro metabolism of 3,4-methylenedioxymethamphetamine in human hepatocytes.

Authors:  Corinne Ramaley; Susan C Leonard; Jeffrey D Miller; Denita Takesha-Mashia Wilson; Sai Y Chang; Qingyu Chen; Feng Li; Chengan Du
Journal:  J Anal Toxicol       Date:  2014-03-28       Impact factor: 3.367

3.  Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.

Authors:  Q David Walker; Christina N Williams; Rakesh P Jotwani; Samuel T Waller; Reynold Francis; Cynthia M Kuhn
Journal:  Psychopharmacology (Berl)       Date:  2006-09-23       Impact factor: 4.530

Review 4.  The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs.

Authors:  H Kalant
Journal:  CMAJ       Date:  2001-10-02       Impact factor: 8.262

Review 5.  Neuroimaging and drug taking in primates.

Authors:  Kevin S Murnane; Leonard L Howell
Journal:  Psychopharmacology (Berl)       Date:  2011-03-01       Impact factor: 4.530

6.  Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes.

Authors:  Iain S McGregor; Clint G Gurtman; Kirsten C Morley; Kelly J Clemens; Arjan Blokland; Kong M Li; Jennifer L Cornish; Glenn E Hunt
Journal:  Psychopharmacology (Berl)       Date:  2003-04-17       Impact factor: 4.530

7.  Psychiatric profiles of mothers who take Ecstasy/MDMA during pregnancy: reduced depression 1 year after giving birth and quitting Ecstasy.

Authors:  John J D Turner; Andrew C Parrott; Julia Goodwin; Derek G Moore; Sarah Fulton; Meeyoung O Min; Lynn T Singer
Journal:  J Psychopharmacol       Date:  2013-12-10       Impact factor: 4.153

Review 8.  Nonhuman primate neuroimaging and the neurobiology of psychostimulant addiction.

Authors:  Leonard L Howell; Kevin S Murnane
Journal:  Ann N Y Acad Sci       Date:  2008-10       Impact factor: 5.691

9.  Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA.

Authors:  A Richard Green; Veronica Sanchez; Esther O'Shea; Kathryn S Saadat; J Martin Elliott; M Isabel Colado
Journal:  Psychopharmacology (Berl)       Date:  2004-01-15       Impact factor: 4.530

10.  Functional MRI study of working memory in MDMA users.

Authors:  F Gerard Moeller; Joel L Steinberg; Donald M Dougherty; Ponnada A Narayana; Larry A Kramer; Perry F Renshaw
Journal:  Psychopharmacology (Berl)       Date:  2004-06-18       Impact factor: 4.530
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