I Hilger1, R Hergt, W A Kaiser. 1. Institut für Diagnostische und Interventionelle Radiologie des Klinikums der Friedrich-Schiller Universität, Jena, Germany.
Abstract
RATIONALE AND OBJECTIVES: To study the effects of magnetic thermoablation in muscle tissue from cow to assess interrelations that might be relevant for a minimally invasive therapy system in the long term. METHODS: Magnetite particles (50-180 mg) were placed in muscle tissue. Temperature elevations as a function of time and distance from the center of the magnetite deposition area were measured during the exposure (up to 304 seconds) to an alternating magnetic field (frequency 400 kHz, amplitude 6.5 kA/m) generated by a circular coil (diameter 90 mm). Measured curves were reproduced by numerical calculations. Tissue alterations, macroscopically visible as light-brown discoloration, were recorded by volume estimations and histopathologic studies. RESULTS: Significant temperature elevations (up to 87 degrees C) were reported within a distance of less than 15 mm from the magnetite deposition area. High initial heating rates were observed during the first 150 seconds of heating. The reproduction of the measured curves by numerical calculations was good (SD = 0.7 degrees C). The theoretical simulation was verified and applied to situations beyond the range of experimental conditions. Damaged tissue comprised pyknotic cell nuclei and degenerated myofibrils. Corresponding volumes were found to be up to 10 times higher than the volume of iron oxide dispersion. CONCLUSIONS: The data demonstrate the applicability of local magnetic thermoablation for therapy of muscle lesions in the long term.
RATIONALE AND OBJECTIVES: To study the effects of magnetic thermoablation in muscle tissue from cow to assess interrelations that might be relevant for a minimally invasive therapy system in the long term. METHODS: Magnetite particles (50-180 mg) were placed in muscle tissue. Temperature elevations as a function of time and distance from the center of the magnetite deposition area were measured during the exposure (up to 304 seconds) to an alternating magnetic field (frequency 400 kHz, amplitude 6.5 kA/m) generated by a circular coil (diameter 90 mm). Measured curves were reproduced by numerical calculations. Tissue alterations, macroscopically visible as light-brown discoloration, were recorded by volume estimations and histopathologic studies. RESULTS: Significant temperature elevations (up to 87 degrees C) were reported within a distance of less than 15 mm from the magnetite deposition area. High initial heating rates were observed during the first 150 seconds of heating. The reproduction of the measured curves by numerical calculations was good (SD = 0.7 degrees C). The theoretical simulation was verified and applied to situations beyond the range of experimental conditions. Damaged tissue comprised pyknotic cell nuclei and degenerated myofibrils. Corresponding volumes were found to be up to 10 times higher than the volume of iron oxide dispersion. CONCLUSIONS: The data demonstrate the applicability of local magnetic thermoablation for therapy of muscle lesions in the long term.
Authors: Min Jeong Jeon; Cheol-Hee Ahn; Hyeonjin Kim; In Jae Chung; Seulhee Jung; Young-Hwa Kim; Hyewon Youn; Jin Wook Chung; Young Il Kim Journal: J Exp Clin Cancer Res Date: 2014-07-18