Literature DB >> 10719085

Antinociceptive effects of calcitonin gene-related peptide injected into periaqueductal grey of rats with mononeuropathy.

S Xu1, T Lundeberg, L Yu.   

Abstract

Intra-periaqueductal grey (PAG) injection of calcitonin gene-related peptide (CGRP) induced dose-dependent increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with mononeuropathy. CGRP-induced increases in HWLs were blocked by intra-PAG injection of the CGRP antagonist CGRP8-37. The results demonstrated that CGRP and CGRP receptors in PAG play an important role in antinociception in rats with mononeuropathy.

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Year:  2000        PMID： 10719085     DOI： 10.1016/s0006-8993(99)02407-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  3 in total

Review 1.  CGRP and the Trigeminal System in Migraine.

Authors:  Smriti Iyengar; Kirk W Johnson; Michael H Ossipov; Sheena K Aurora
Journal:  Headache       Date:  2019-04-14       Impact factor: 5.887

2.  CGRP Induces Differential Regulation of Cytokines from Satellite Glial Cells in Trigeminal Ganglia and Orofacial Nociception.

Authors:  Shaista Afroz; Rieko Arakaki; Takuma Iwasa; Masamitsu Oshima; Maki Hosoki; Miho Inoue; Otto Baba; Yoshihiro Okayama; Yoshizo Matsuka
Journal:  Int J Mol Sci       Date:  2019-02-07       Impact factor: 5.923

Review 3.  The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine.

Authors:  Smriti Iyengar; Michael H Ossipov; Kirk W Johnson
Journal:  Pain       Date:  2017-04       Impact factor: 7.926
  3 in total

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