Literature DB >> 10718318

Co-localization of patched and activated sonic hedgehog to lysosomes in neurons.

F G Mastronardi1, J Dimitroulakos, S Kamel-Reid, A S Manoukian.   

Abstract

We demonstrate co-localization of the Patched 1 (Ptc1) receptor and its ligand sonic hedgehog (Shh) in lysosomes suggests an intracellular sorting mechanism for this receptor and its ligand. Treatment of murine brain primary cultures and a human teratoma cell line with the N-terminal activated form of Shh (ShhNT), a Ptc1-Shh complex was observed in lysosomes. Consistent with this interaction, Western immunoblot analysis revealed intracellular localization of native Ptc1 and ShhNT. Examination of the topological model of the Ptc1 receptor revealed a number of Yxxphi lysosomal targeting sequences consistent with our observations for Ptc1 sorting.

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Year:  2000        PMID： 10718318     DOI： 10.1097/00001756-200002280-00030

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  10 in total

1.  Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia.

Authors:  Erica Nieuwenhuis; Jun Motoyama; Paul C Barnfield; Yoshiaki Yoshikawa; Xiaoyun Zhang; Rong Mo; Michael A Crackower; Chi-Chung Hui
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

Review 2.  The role of the Hedgehog signaling pathway in cancer: A comprehensive review.

Authors:  Ana Marija Skoda; Dora Simovic; Valentina Karin; Vedran Kardum; Semir Vranic; Ljiljana Serman
Journal:  Bosn J Basic Med Sci       Date:  2018-02-20       Impact factor: 3.363

Review 3.  Exploring Sonic Hedgehog Cell Signaling in Neurogenesis: Its Potential Role in Depressive Behavior.

Authors:  Tarapati Rana; Tapan Behl; Aayush Sehgal; Monika Sachdeva; Vineet Mehta; Neelam Sharma; Sukhbir Singh; Simona Bungau
Journal:  Neurochem Res       Date:  2021-03-30       Impact factor: 3.996

Review 4.  The crosstalk between long non-coding RNAs and the hedgehog signaling pathway in cancer.

Authors:  Marzieh Lotfian Sargazi; Saeideh Jafarinejad-Farsangi; Maryam Moazzam-Jazi; Farzaneh Rostamzadeh; Zahra Miri Karam
Journal:  Med Oncol       Date:  2022-06-18       Impact factor: 3.064

Review 5.  Noncoding RNAs related to the hedgehog pathway in cancer: clinical implications and future perspectives.

Authors:  Jia Song; Yuexin Ge; Xiaoyu Sun; Qiutong Guan; Shiqiang Gong; Minjie Wei; Jumin Niu; Lin Zhao
Journal:  Mol Cancer       Date:  2022-05-17       Impact factor: 41.444

6.  Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

Authors:  Abdiwahab A Musse; Zhen Li; Cameron A Ackerley; Dorothee Bienzle; Helena Lei; Roberto Poma; George Harauz; Mario A Moscarello; Fabrizio G Mastronardi
Journal:  Dis Model Mech       Date:  2008-11-06       Impact factor: 5.758

7.  Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation.

Authors:  Christelle Adolphe; Erica Nieuwenhuis; Rehan Villani; Zhu Juan Li; Pritinder Kaur; Chi-Chung Hui; Brandon J Wainwright
Journal:  J Invest Dermatol       Date:  2014-02-03       Impact factor: 8.551

8.  Hedgehog signaling activation induces stem cell proliferation and hormone release in the adult pituitary gland.

Authors:  Joanna Pyczek; Rolf Buslei; David Schult; Annett Hölsken; Michael Buchfelder; Ina Heß; Heidi Hahn; Anja Uhmann
Journal:  Sci Rep       Date:  2016-04-25       Impact factor: 4.379

Review 9.  Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells.

Authors:  Ita Novita Sari; Lan Thi Hanh Phi; Nayoung Jun; Yoseph Toni Wijaya; Sanghyun Lee; Hyog Young Kwon
Journal:  Cells       Date:  2018-11-10       Impact factor: 6.600

Review 10.  Hedgehog signaling regulates the development and treatment of glioblastoma.

Authors:  Hongping Wang; Qun Lai; Dayong Wang; Jian Pei; Baogang Tian; Yunhe Gao; Zhaoguo Gao; Xiang Xu
Journal:  Oncol Lett       Date:  2022-07-05       Impact factor: 3.111
  10 in total

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