Literature DB >> 10718291

High frequency stimulation of the subthalamic nucleus influences striatal dopaminergic metabolism in the naive rat.

G Paul1, T Reum, W Meissner, A Marburger, R Sohr, R Morgenstern, A Kupsch.   

Abstract

High frequency stimulation (HFS) of the subthalamic nucleus (STN) can partially alleviate motor symptoms in patients with Parkinson's disease (PD). However, the mechanism of action of HFS is incompletely understood. We investigated the effect of HFS (130 Hz) and low frequency stimulation (LFS, 20 Hz) of the STN on striatal dopaminergic transmission and metabolism using in vivo microdialysis in anaesthetized and freely moving rats. While LFS had no effect, HFS of the STN produced a delayed, stable and intensity-dependent increase of extracellular dopamine metabolites. Striatal extracellular levels of dopamine and 5-HIAA were not influenced by HFS or LFS in the present experimental paradigm. We conclude that HFS of the STN influences striatal dopaminergic metabolism in naive, nonlesioned rats.

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Year:  2000        PMID： 10718291     DOI： 10.1097/00001756-200002280-00003

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  18 in total

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Review 5.  Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation.

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Journal:  Neurosci Biobehav Rev       Date:  2015-02-12       Impact factor: 8.989

Review 6.  Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects.

Authors:  Jonathan E Rubin; Cameron C McIntyre; Robert S Turner; Thomas Wichmann
Journal:  Eur J Neurosci       Date:  2012-07       Impact factor: 3.386

7.  Emerging techniques for elucidating mechanism of action of deep brain stimulation.

Authors:  Kendall H Lee; Su-Youne Chang; Dong-Pyo Jang; Inyong Kim; Stephan Goerss; Jamie Van Gompel; Paul Min; Kanika Arora; Michael Marsh; Sun Chul Hwang; Christopher J Kimble; Paul Garris; Charles Blaha; Kevin E Bennet
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8.  High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats.

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9.  High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model.

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Journal:  J Comput Neurosci       Date:  2004 May-Jun       Impact factor: 1.621

10.  High-frequency stimulation of the subthalamic nucleus selectively reverses dopamine denervation-induced cellular defects in the output structures of the basal ganglia in the rat.

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Journal:  J Neurosci       Date:  2002-06-15       Impact factor: 6.167
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