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Literature DB >> 10717473

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

Abstract

Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia.

Entities: Disease Gene

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Year: 2000 PMID： 10717473 DOI： 10.1016/s0378-1119(00)00014-7

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

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Cited

53 in total

1. Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression.

Authors: Hugh N Nuthall; Junaid Husain; Keith W McLarren; Stefano Stifani
Journal: Mol Cell Biol Date: 2002-01 Impact factor: 4.272

2. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.

Authors: S Tsuzuki; M Towatari; H Saito; T Enver
Journal: Mol Cell Biol Date: 2000-09 Impact factor: 4.272

10. AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons.

Authors: Francesca M Theriault; Priscillia Roy; Stefano Stifani
Journal: Proc Natl Acad Sci U S A Date: 2004-07-06 Impact factor: 11.205

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

1. Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression.

2. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.

Review 3. Galectin genes: regulation of expression.

4. The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes.

Review 5. The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility.

6. Differential chromatin looping regulates CD4 expression in immature thymocytes.

7. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.

Review 8. Emergence of zebrafish models in oncology for validating novel anticancer drug targets and nanomaterials.

Review 9. Runx1/AML1 in normal and abnormal hematopoiesis.

10. AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons.