Literature DB >> 1071696

Pharmacokinetic and pharmacological studies with clonidine in normal subjects.

D S Davies, L M Wing, J L Reid, P Tippett, C T Dollery.   

Abstract

1. A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. 2. Plasma half-lives of clonidine ranged from 6-9 to 9-4 h in five normotensive subjects. 3. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

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Year:  1976        PMID: 1071696     DOI: 10.1042/cs051639s

Source DB:  PubMed          Journal:  Clin Sci Mol Med Suppl        ISSN: 0144-4107


  1 in total

1.  Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study.

Authors:  Estelle B Gauda; Raul Chavez-Valdez; Frances J Northington; Carlton K K Lee; Michelle A Rudek; Beatriz Guglieri-Lopez; Vijay Ivaturi
Journal:  J Perinatol       Date:  2021-09-16       Impact factor: 2.521

  1 in total

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