BACKGROUND: Aggressive angiomyxoma is a rare mesenchymal tumor, characterized by frequent local recurrences. Our aim is to assess the role of radical resection. METHODS: Retrospective case review. The records of five patients with aggressive angiomyxoma during the period from 1984 to 1998 were reviewed and analyzed. A MEDLINE search from 1983 to May 1999 was performed. The clinical presentation, surgical treatment, resection margin involvement and clinical outcomes were analyzed. RESULTS: Together with our five cases, 106 cases have been reported in the world literature. The female-to-male ratio was 6.6:1. The age distribution was wide, with the peak incidence at 31 to 35. The local recurrence rate was high. Seventy-one percent of recurrence occurred within the first 3 years. Patients with clear resection margins have similar chances of remaining disease-free compared with those having tumor-involved resection margins. There was no correlation between the size of the tumors and the chance of recurrence. CONCLUSIONS: Though we aim for complete resection, incomplete or partial resection is acceptable, especially when high operative morbidity is anticipated and preservation of fertility is an issue. Long-term follow-up and careful monitoring with imaging techniques are essential for timely identification of recurrence and prompt resection.
BACKGROUND:Aggressive angiomyxoma is a rare mesenchymal tumor, characterized by frequent local recurrences. Our aim is to assess the role of radical resection. METHODS: Retrospective case review. The records of five patients with aggressive angiomyxoma during the period from 1984 to 1998 were reviewed and analyzed. A MEDLINE search from 1983 to May 1999 was performed. The clinical presentation, surgical treatment, resection margin involvement and clinical outcomes were analyzed. RESULTS: Together with our five cases, 106 cases have been reported in the world literature. The female-to-male ratio was 6.6:1. The age distribution was wide, with the peak incidence at 31 to 35. The local recurrence rate was high. Seventy-one percent of recurrence occurred within the first 3 years. Patients with clear resection margins have similar chances of remaining disease-free compared with those having tumor-involved resection margins. There was no correlation between the size of the tumors and the chance of recurrence. CONCLUSIONS: Though we aim for complete resection, incomplete or partial resection is acceptable, especially when high operative morbidity is anticipated and preservation of fertility is an issue. Long-term follow-up and careful monitoring with imaging techniques are essential for timely identification of recurrence and prompt resection.
Authors: Giovanni Fucà; Nadia Hindi; Isabelle Ray-Coquard; Vittoria Colia; Angelo Paolo Dei Tos; Javier Martin-Broto; Mehdi Brahmi; Paola Collini; Domenica Lorusso; Francesco Raspagliesi; Maria Abbondanza Pantaleo; Bruno Vincenzi; Elena Fumagalli; Alessandro Gronchi; Paolo Giovanni Casali; Roberta Sanfilippo Journal: Oncologist Date: 2018-12-05
Authors: Nivedita Sharma; Than Singh Tomar; Arun Peter Mathew; K Chandramohan; R Preethi; Rari P Mony Journal: Indian J Surg Date: 2017-06-04 Impact factor: 0.656