S Gu1, H Zhang, L Zhang. 1. Department of Infectious Disease, Nanfang Hospital, Guangzhou.
Abstract
OBJECTIVE: To study relation of serum fibrosis markers with quantitative analysis of liver tissue. METHODS: We studied the area of reticular fibrin, collagen fibrin and elasticity fibrin in 77 patients with chronic liver disease using color image analysis system. RESULTS: From S0 to S4, the area of three kinds of liver fibrosis were all escalate, especially collagen fibrosis. Prominent differences existed between S3 and S2, S2 and S1, S1 and S0. There was a good correlation between the serum fibrosis markers and area of collagen fibrosis of liver tissue, r = 0.70775(HA), 0.59402(CIV), 0.52593(LN), 0.52198 (hPCIII). CONCLUSIONS: Serum fibrosis markers have affirmative value to help diagnose liver fibrosis.
OBJECTIVE: To study relation of serum fibrosis markers with quantitative analysis of liver tissue. METHODS: We studied the area of reticular fibrin, collagen fibrin and elasticity fibrin in 77 patients with chronic liver disease using color image analysis system. RESULTS: From S0 to S4, the area of three kinds of liver fibrosis were all escalate, especially collagen fibrosis. Prominent differences existed between S3 and S2, S2 and S1, S1 and S0. There was a good correlation between the serum fibrosis markers and area of collagen fibrosis of liver tissue, r = 0.70775(HA), 0.59402(CIV), 0.52593(LN), 0.52198 (hPCIII). CONCLUSIONS: Serum fibrosis markers have affirmative value to help diagnose liver fibrosis.