Literature DB >> 10714503

Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.

H Yanagisawa1, M Takamura, E Yamada, S Fujita, T Fujiwara, M Yachi, A Isobe, Y Hagisawa.   

Abstract

Oximes having 5-benzyl-2,4-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evaluated. Biaromatic and methyl groups, attached to the oxime moiety, and the ethylene bridge between oxime and phenoxy groups are favorable to biological activities.

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Year:  2000        PMID: 10714503     DOI: 10.1016/s0960-894x(00)00003-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Pharmacophore modeling and parallel screening for PPAR ligands.

Authors:  Patrick Markt; Daniela Schuster; Johannes Kirchmair; Christian Laggner; Thierry Langer
Journal:  J Comput Aided Mol Des       Date:  2007-10-25       Impact factor: 3.686

2.  Synthesis and Antimicrobial Evaluation of Dibenzo[b,e]oxepin-11(6H)-one O-Benzoyloxime Derivatives.

Authors:  Bassem Sadek; Carmen Limban; Camelia Elena Stecoza; Sigurd Elz
Journal:  Sci Pharm       Date:  2011-09-18
  2 in total

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