| Literature DB >> 10714432 |
D Drugarin1, S Negru, A Koreck, I Zosin, C Cristea.
Abstract
This study performed on 51 patients with autoimmune thyroiditis and 15 healthy subjects was aimed at correlating the activation of T cells and the secretion of inflammatory cytokine with echography and thyroid functional assays. A significant increase of activated T cells was observed in Hashimoto patients illustrated by an increased percentage of CD3+ CD25+ T cells (P < 0.01). Similarly, increased amounts of IL-2, TNF-alpha and IFN-gamma were in the serum of patients compared with the control group in which these cytokines are barely detectable. An in vitro study shows a significant increase of IL-2 and TNF-alpha upon the exposure to Concanavalin A. These results suggest that T(H)1 secreting inflammatory cytokines may contribute to pathogenesis of autoimmune thyroiditis.Entities:
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Year: 2000 PMID： 10714432 DOI： 10.1016/s0165-2478(99)00156-x
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685