Literature DB >> 10713410

The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats.

Z Li1, Y Yamamoto, T Morimoto, J Ono, S Okada, A Yamatodani.   

Abstract

We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was observed in the non-kindled rats when the same grade seizure was induced by PTZ. The convulsive dose of PTZ administration caused a decrease in taurine levels in the controls, however, no significant changes were found in the kindled rats.

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Year:  2000        PMID： 10713410     DOI： 10.1016/s0304-3940(00)00838-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  3 in total

1.  Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice.

Authors:  Nina Isoherranen; Boris Yagen; Ofer Spiegelstein; Richard H Finnell; Michelle Merriweather; Jose H Woodhead; Bogdan Wlodarczyk; H Steve White; Meir Bialer
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

2.  Effects of cocaine-kindling on the expression of NMDA receptors and glutamate levels in mouse brain.

Authors:  Rafal M Kaminski; Juan F Núñez-Taltavull; Bogusława Budziszewska; Władysław Lasoń; Maciej Gasior; Agustin Zapata; Toni S Shippenberg; Jeffrey M Witkin
Journal:  Neurochem Res       Date:  2010-10-07       Impact factor: 3.996

3.  Decreased epileptogenesis in mice lacking the System xc - transporter occurs in association with a reduction in AMPA receptor subunit GluA1.

Authors:  Sheila M S Sears; James A Hewett; Sandra J Hewett
Journal:  Epilepsia Open       Date:  2019-02-21
  3 in total

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