Literature DB >> 10713349

PU.1 expression in microglia.

M R Walton1, H Gibbons, G A MacGibbon, E Sirimanne, J Saura, P D Gluckman, M Dragunow.   

Abstract

The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in microglial regulation, we investigated its expression following hypoxic-ischemia (HI) brain injury and in the BV-2 microglial cell line. We found that microglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states.

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Year:  2000        PMID： 10713349     DOI： 10.1016/s0165-5728(99)00262-3

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  18 in total

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Review 9.  Microglia development and function.

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