Literature DB >> 10712721

Can a dose of 2microg.kg(-1) caudal clonidine cause respiratory depression in neonates?

C Breschan1, R Krumpholz, R Likar, R Kraschl, H V Schalk.   

Abstract

A case of multiple life-threatening postoperative apnoeas in a term neonate undergoing inguinal herniorrhaphy and orchidopexy who received light inhalation anaesthesia combined with caudal block with 1 ml.kg-1 ropivacaine 0.2% plus 2 microg.kg-1 clonidine is reported. The patient showed no apparent risk factors for postanaesthetic apnoea. Oxycardiorespirography five days after surgery only showed minor abnormalities. Clonidine though administered caudally in the usual dose of 2 microg.kg-1 appeared to be the most likely cause for postanaesthetic apnoea in this neonate.

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Year:  1999        PMID： 10712721

Source DB:  PubMed          Journal:  Paediatr Anaesth        ISSN： 1155-5645            Impact factor:   2.556


  12 in total

1.  Neonates have a spinal alpha receptor too, as do adults.

Authors:  T L Yaksh
Journal:  Br J Pharmacol       Date:  2007-07-16       Impact factor: 8.739

Review 2.  [Anesthetic management of surgery in term and preterm infants].

Authors:  C Breschan; R Likar
Journal:  Anaesthesist       Date:  2006-10       Impact factor: 1.041

3.  Efficacy and Safety of Clonidine as an Adjuvant to Bupivacaine for Caudal Analgesia in Paediatric Infra-Umbilical Surgeries.

Authors:  Samita Priolkar; Shirley Ann D'Souza
Journal:  J Clin Diagn Res       Date:  2016-09-01

4.  Intrathecal clonidine in the neonatal rat: dose-dependent analgesia and evaluation of spinal apoptosis and toxicity.

Authors:  Suellen M Walker; Marjorie Grafe; Tony L Yaksh
Journal:  Anesth Analg       Date:  2012-03-30       Impact factor: 5.108

5.  [Regional anesthesia procedures in childhood: Austrian interdisciplinary recommendations on pediatric perioperative pain management].

Authors:  B Messerer; M Platzer; C Justin; M Vittinghoff
Journal:  Schmerz       Date:  2014-02       Impact factor: 1.107

6.  Clonidine in paediatrics - a review.

Authors:  Sujatha Basker; Georgene Singh; Rebecca Jacob
Journal:  Indian J Anaesth       Date:  2009-06

Review 7.  Neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data.

Authors:  Suellen M Walker; Tony L Yaksh
Journal:  Anesth Analg       Date:  2012-07-13       Impact factor: 5.108

8.  Recent developments in paediatric neuraxial blocks.

Authors:  Vrushali Chandrashekhar Ponde
Journal:  Indian J Anaesth       Date:  2012-09

9.  Efficacy of clonidine as an adjuvant to bupivacaine for caudal analgesia in children undergoing sub-umbilical surgery.

Authors:  Aruna Parameswari; Anand M Dhev; Mahesh Vakamudi
Journal:  Indian J Anaesth       Date:  2010-09

10.  Adjuvants to local anesthetics: Current understanding and future trends.

Authors:  Amlan Swain; Deb Sanjay Nag; Seelora Sahu; Devi Prasad Samaddar
Journal:  World J Clin Cases       Date:  2017-08-16       Impact factor: 1.337
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