Literature DB >> 10710415

SURVEY AND SUMMARY: Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes.

K A Robinson1, J M Lopes.   

Abstract

Basic helix-loop-helix (bHLH) proteins are among the most well studied and functionally important regulatory proteins in all eukaryotes. The HLH domain dictates dimerization to create homo- and heterodimers. Dimerization juxtaposes the basic regions of the two monomers to create a DNA interaction surface that recognizes the consensus sequence called the E-box, 5'-CANNTG-3'. Several bHLH proteins have been identified in the yeast Saccharomyces cerevisiae using traditional genetic methodologies. These proteins regulate diverse biological pathways. The completed sequence of the yeast genome, combined with novel methodologies allowing whole-genome expression studies, now offers a unique opportunity to study the function of these bHLH proteins. It is the purpose of this review to summarize the current knowledge of bHLH protein function in yeast.

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Year:  2000        PMID： 10710415      PMCID： PMC102793          DOI： 10.1093/nar/28.7.1499

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  62 in total

1.  The yeast regulatory gene PHO4 encodes a helix-loop-helix motif.

Authors:  G Berben; M Legrain; V Gilliquet; F Hilger
Journal:  Yeast       Date:  1990 Sep-Oct       Impact factor: 3.239

2.  The acid phosphatase genes PHO10 and PHO11 in S. cerevisiae are located at the telomeres of chromosomes VIII and I.

Authors:  U Venter; W Hörz
Journal:  Nucleic Acids Res       Date:  1989-02-25       Impact factor: 16.971

3.  Function of the PHO regulatory genes for repressible acid phosphatase synthesis in Saccharomyces cerevisiae.

Authors:  K Yoshida; N Ogawa; Y Oshima
Journal:  Mol Gen Genet       Date:  1989-05

4.  A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function.

Authors:  Z Liu; R A Butow
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

5.  The Saccharomyces cerevisiae INO4 gene encodes a small, highly basic protein required for derepression of phospholipid biosynthetic enzymes.

Authors:  D K Hoshizaki; J E Hill; S A Henry
Journal:  J Biol Chem       Date:  1990-03-15       Impact factor: 5.157

6.  Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy.

Authors:  M Cai; R W Davis
Journal:  Cell       Date:  1990-05-04       Impact factor: 41.582

7.  Yeast fructose-2,6-bisphosphate 6-phosphatase is encoded by PHO8, the gene for nonspecific repressible alkaline phosphatase.

Authors:  U Plankert; C Purwin; H Holzer
Journal:  Eur J Biochem       Date:  1991-02-26

8.  The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions.

Authors:  K Vogel; W Hörz; A Hinnen
Journal:  Mol Cell Biol       Date:  1989-05       Impact factor: 4.272

9.  Identification of the yeast methionine biosynthetic genes that require the centromere binding factor 1 for their transcriptional activation.

Authors:  L Kuras; D Thomas
Journal:  FEBS Lett       Date:  1995-06-19       Impact factor: 4.124

10.  CPF1, a yeast protein which functions in centromeres and promoters.

Authors:  J Mellor; W Jiang; M Funk; J Rathjen; C A Barnes; T Hinz; J H Hegemann; P Philippsen
Journal:  EMBO J       Date:  1990-12       Impact factor: 11.598
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  55 in total

1.  Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein.

Authors:  P Leng; P R Lee; H Wu; A J Brown
Journal:  J Bacteriol       Date:  2001-07       Impact factor: 3.490

2.  Oligomerization mediated by a helix-loop-helix-like domain of baculovirus IE1 is required for early promoter transactivation.

Authors:  V A Olson; J A Wetter; P D Friesen
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

3.  The glycerophosphocholine acyltransferase Gpc1 is part of a phosphatidylcholine (PC)-remodeling pathway that alters PC species in yeast.

Authors:  Sanket Anaokar; Ravindra Kodali; Benjamin Jonik; Mike F Renne; Jos F H M Brouwers; Ida Lager; Anton I P M de Kroon; Jana Patton-Vogt
Journal:  J Biol Chem       Date:  2018-12-04       Impact factor: 5.157

4.  Phylogenetic analysis and classification of the fungal bHLH domain.

Authors:  Joshua K Sailsbery; William R Atchley; Ralph A Dean
Journal:  Mol Biol Evol       Date:  2011-11-22       Impact factor: 16.240

5.  Derepression of INO1 transcription requires cooperation between the Ino2p-Ino4p heterodimer and Cbf1p and recruitment of the ISW2 chromatin-remodeling complex.

Authors:  Ameet Shetty; John M Lopes
Journal:  Eukaryot Cell       Date:  2010-10-08

6.  Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.

Authors:  Vivien Measday; Kristin Baetz; Julie Guzzo; Karen Yuen; Teresa Kwok; Bilal Sheikh; Huiming Ding; Ryo Ueta; Trinh Hoac; Benjamin Cheng; Isabelle Pot; Amy Tong; Yuko Yamaguchi-Iwai; Charles Boone; Phil Hieter; Brenda Andrews
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-19       Impact factor: 11.205

7.  Connecting protein structure with predictions of regulatory sites.

Authors:  Alexandre V Morozov; Eric D Siggia
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-16       Impact factor: 11.205

8.  A fitness-based interferential genetics approach using hypertoxic/inactive gene alleles as references.

Authors:  Jacques H Daniel
Journal:  Mol Genet Genomics       Date:  2009-01-17       Impact factor: 3.291

9.  Genome-wide classification and evolutionary analysis of the bHLH family of transcription factors in Arabidopsis, poplar, rice, moss, and algae.

Authors:  Lorenzo Carretero-Paulet; Anahit Galstyan; Irma Roig-Villanova; Jaime F Martínez-García; Jose R Bilbao-Castro; David L Robertson
Journal:  Plant Physiol       Date:  2010-05-14       Impact factor: 8.340

10.  IN02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeast.

Authors:  Laura Block-Alper; Paul Webster; Xianghong Zhou; Lubica Supeková; Wing Hung Wong; Peter G Schultz; David I Meyer
Journal:  Mol Biol Cell       Date:  2002-01       Impact factor: 4.138
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