Continuous infusion of the conjunctival sac with pilocarpine in normal subjects and in patients with chronic glaucoma.

(1) A drug solution can be infused into the conjunctival sac by a simple method that does not cause overflow of solution. (2) At near neutral pH, pilocarpine infused at 1 mug/min was as effective as a single dose of 125 mug as a pupilloconstrictor in normal subjects. (3) At near neutral pH, pilocarpine infused at 10 mug/min was as effective as a single dose of 1 mg as an ocular hypotensive in cases of chronic simple glaucoma. (4) The infusion system described could find application in those situations in which it is essential to maintain a known and constant concentration of drug in the conjunctival sac.