Literature DB >> 10708405

Quantitative analysis of urinary acylglycines for the diagnosis of beta-oxidation defects using GC-NCI-MS.

C G Costa1, W S Guérand, E A Struys, U Holwerda, H J ten Brink, I Tavares de Almeida, M Duran, C Jakobs.   

Abstract

The analysis of acylglycines is an important biochemical tool for the diagnosis of inherited disorders of mitochondrial fatty acid beta-oxidation. A stable isotope dilution gas chromatography negative chemical ionisation mass spectrometry method for the quantitative analysis of short- and medium-chain acylglycines as their bis(trifluoromethyl)benzyl (BTFMB) ester derivatives is described. The diagnostic usefulness of the method was demonstrated in nine patients with medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) deficiency, and seven patients with multiple acyl-CoA dehydrogenation defect (MAD). The urinary acylglycine profiles in these patients were compared to those in controls (n = 19), children on a medium-chain triglyceride (MCT) supplemented diet (n = 4), and patients with various other diseases (n = 5).

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Year:  2000        PMID： 10708405     DOI： 10.1016/s0731-7085(99)00235-6

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  7 in total

1.  A method for comprehensive analysis of urinary acylglycines by using ultra-performance liquid chromatography quadrupole linear ion trap mass spectrometry.

Authors:  Avalyn E Lewis-Stanislaus; Liang Li
Journal:  J Am Soc Mass Spectrom       Date:  2010-09-18       Impact factor: 3.109

2.  Fecal Microbiota Transplantation in Experimental Ulcerative Colitis Reveals Associated Gut Microbial and Host Metabolic Reprogramming.

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Journal:  Appl Environ Microbiol       Date:  2018-07-02       Impact factor: 4.792

3.  Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.

Authors:  Erin L Glynn; Lucy W Piner; Kim M Huffman; Cris A Slentz; Lorraine Elliot-Penry; Hiba AbouAssi; Phillip J White; James R Bain; Michael J Muehlbauer; Olga R Ilkayeva; Robert D Stevens; Kathryn N Porter Starr; Connie W Bales; Elena Volpi; M Julia Brosnan; Jeff K Trimmer; Timothy P Rolph; Christopher B Newgard; William E Kraus
Journal:  Diabetologia       Date:  2015-08-09       Impact factor: 10.122

4.  Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.

Authors:  Kim M Huffman; Cris A Slentz; Lori A Bateman; Dana Thompson; Michael J Muehlbauer; James R Bain; Robert D Stevens; Brett R Wenner; Virginia Byers Kraus; Christopher B Newgard; William E Kraus
Journal:  Diabetes Care       Date:  2010-10-04       Impact factor: 19.112

5.  Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing.

Authors:  Daniel J Wilkinson; Giovanny Rodriguez-Blanco; Warwick B Dunn; Bethan E Phillips; John P Williams; Paul L Greenhaff; Kenneth Smith; Iain J Gallagher; Philip J Atherton
Journal:  Aging (Albany NY)       Date:  2020-06-24       Impact factor: 5.682

6.  Understanding the tonifying and the detoxifying properties of Chinese medicines from their impacts on gut microbiota and host metabolism: a case study with four medicinal herbs in experimental colitis rat model.

Authors:  Ting Li; Xuejiao Gao; Zhixiang Yan; Tai-Seng Wai; Wei Yang; Junru Chen; Ru Yan
Journal:  Chin Med       Date:  2022-10-04       Impact factor: 4.546

7.  Urine dicarboxylic acids change in pre-symptomatic Alzheimer's disease and reflect loss of energy capacity and hippocampal volume.

Authors:  K J Castor; S Shenoi; S P Edminster; T Tran; K S King; H Chui; J M Pogoda; A N Fonteh; M G Harrington
Journal:  PLoS One       Date:  2020-04-16       Impact factor: 3.240
  7 in total

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