| Literature DB >> 10706961 |
M Eberl1, E Beck, P S Coulson, H Okamura, R A Wilson, A P Mountford.
Abstract
Due to the synergistic effects of IL-12 and IL-18, and to their importance in establishing a Th1 type immune response, we investigated the potential of a combined administration of both cytokines as an adjuvant for recombinant antigens. As a model system, we used a schistosome T cell antigen recently identified in our group. By co-adsorption of this antigen on alum in the presence of IL-12 and IL-18, we demonstrate that IL-18 enhances the effects of IL-12 in inducing an antigen-specific Th1 type CD4(+) T cell response as well as high titres of IgG1, IgG2a, and IgG2b antibodies.Entities:
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Year: 2000 PMID： 10706961 DOI： 10.1016/s0264-410x(99)00532-0
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641