Literature DB >> 10706709

A putative 12 transmembrane domain cotransporter expressed in thymic cortical epithelial cells.

M G Kim1, F A Flomerfelt, K N Lee, C Chen, R H Schwartz.   

Abstract

We have isolated a full-length cDNA clone (thymic stromal origin (TSO)-1C12) from a SCID thymus library using a probe from a PCR-based subtractive library enriched for sequences from fetal thymic stromal cells. TSO-1C12 mRNA is expressed mainly in the thymic cortex and is highly enriched in SCID thymus. Expression per cell is highest during fetal thymus development and decreases after day 16. Antipeptide Abs immunoprecipitated a hydrophobic, plasma membrane glycoprotein (thymic stromal cotransporter, TSCOT) whose translated sequence has weak homology to bacterial antiporters and mammalian cation cotransporters with 12 transmembrane domains. TSCOT represents a new member of this superfamily that is highly expressed in thymic cortical epithelial cells.

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Year:  2000        PMID： 10706709     DOI： 10.4049/jimmunol.164.6.3185

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  8 in total

1.  SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans.

Authors:  Donggi Paik; Amanda Monahan; Daniel R Caffrey; Roland Elling; William E Goldman; Neal Silverman
Journal:  J Immunol       Date:  2017-05-24       Impact factor: 5.422

2.  Thymic epithelial requirement for γδ T cell development revealed in the cell ablation transgenic system with TSCOT promoter.

Authors:  Gwanghee Lee; Ki Yeon Kim; Cheong-Hee Chang; Moon Gyo Kim
Journal:  Mol Cells       Date:  2012-11-15       Impact factor: 5.034

3.  Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis.

Authors:  Malin T Engelmark; Emma L Ivansson; Jessica J Magnusson; Inger M Gustavsson; Per-Ivan Wyöni; Max Ingman; Patrik K E Magnusson; Ulf B Gyllensten
Journal:  Hum Genet       Date:  2008-04-08       Impact factor: 4.132

4.  Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.

Authors:  Ki Yeon Kim; Gwanghee Lee; Minsang Yoon; Eun Hye Cho; Chan-Sik Park; Moon Gyo Kim
Journal:  Mol Cells       Date:  2015-05-27       Impact factor: 5.034

5.  Tolerance to self: which cells kill?

Authors:  Terri M Laufer
Journal:  PLoS Biol       Date:  2008-09-30       Impact factor: 8.029

6.  TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.

Authors:  Sejin Ahn; Gwanghee Lee; Soo Jung Yang; Deokjae Lee; Seunghyuk Lee; Hyo Sun Shin; Min Cheol Kim; Kee Nyung Lee; Douglas C Palmer; Marc R Theoret; Eric J Jenkinson; Graham Anderson; Nicholas P Restifo; Moon Gyo Kim
Journal:  PLoS Biol       Date:  2008-08-05       Impact factor: 8.029

7.  Uptake, recognition and responses to peptidoglycan in the mammalian host.

Authors:  Paulo A D Bastos; Richard Wheeler; Ivo G Boneca
Journal:  FEMS Microbiol Rev       Date:  2021-01-08       Impact factor: 16.408

8.  Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes.

Authors:  Anthony F Cordova; Christopher Ritchie; Volker Böhnert; Lingyin Li
Journal:  ACS Cent Sci       Date:  2021-06-07       Impact factor: 14.553
  8 in total

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