BACKGROUND: Due to possible complications and treatment limitations, the prevention of influenza in renal transplant (RT) patients is highly indicated. METHODS: Forty-nine patients with a 1-year functioning RT subjected to two different immunosuppressive regimens and 37 healthy relatives (HR) were administered the anti-influenza vaccine as recommended for 1996 to 1997. Anti-influenza antibody, creatinine, and immunological markers were estimated at 1 and 3 months after vaccination. RESULTS: Three months after vaccination, 46.2% of the RT patients and 69% of the HR (P=0.06) showed protective antibody titers to influenza A (relative risk [RR]; 0.67; 95% confidence interval: 0.44-1.02). A total of 20.5% of the RT patients and 44.8% of the HR showed antibodies to influenza B (P=0.03). Despite these differences, the incidence of illness was similar. The immunosuppressive regimen had no effect on the antibody response. CONCLUSIONS: Although the RT patients showed a reduced antibody response, no negative effects on graft outcome were observed.
BACKGROUND: Due to possible complications and treatment limitations, the prevention of influenza in renal transplant (RT) patients is highly indicated. METHODS: Forty-nine patients with a 1-year functioning RT subjected to two different immunosuppressive regimens and 37 healthy relatives (HR) were administered the anti-influenza vaccine as recommended for 1996 to 1997. Anti-influenza antibody, creatinine, and immunological markers were estimated at 1 and 3 months after vaccination. RESULTS: Three months after vaccination, 46.2% of the RT patients and 69% of the HR (P=0.06) showed protective antibody titers to influenza A (relative risk [RR]; 0.67; 95% confidence interval: 0.44-1.02). A total of 20.5% of the RT patients and 44.8% of the HR showed antibodies to influenza B (P=0.03). Despite these differences, the incidence of illness was similar. The immunosuppressive regimen had no effect on the antibody response. CONCLUSIONS: Although the RT patients showed a reduced antibody response, no negative effects on graft outcome were observed.
Authors: Vinay Rambal; Karin Müller; Chantip Dang-Heine; Arne Sattler; Mikalai Dziubianau; Benjamin Weist; Si-Hong Luu; Alexandra Stoyanova; Peter Nickel; Andreas Thiel; Avidan Neumann; Brunhilde Schweiger; Petra Reinke; Nina Babel Journal: Med Microbiol Immunol Date: 2013-09-22 Impact factor: 3.402
Authors: Nilufer E Broeders; Anneleen Hombrouck; Anne Lemy; Karl Martin Wissing; Judith Racapé; Karine Gastaldello; Annick Massart; Steven Van Gucht; Laura Weichselbaum; Aurelie De Mul; Bernard Brochier; Isabelle Thomas; Daniel Abramowicz Journal: Clin J Am Soc Nephrol Date: 2011-09-15 Impact factor: 8.237
Authors: Kelly A Birdwell; Mine R Ikizler; Li Wang; Daniel W Byrne; Edith C Sannella; Peter F Wright; T Alp Ikizler Journal: Am J Nephrol Date: 2012-08-17 Impact factor: 3.754