E Cantor-Graae1, B Ismail, T F McNeil. 1. Department of Community Medicine, Lund University, University Hospital, Malmö, Sweden.
Abstract
OBJECTIVE: Previous findings of increased neurological abnormalities in schizophrenic patients and their non-psychotic siblings raise the question of possible causes. The purpose of the present study was to examine the role of perinatal trauma in the aetiology of neurological abnormality. METHOD: Obstetric information obtained from hospital records for 55 schizophrenic patients and 19 non-psychotic siblings was scored blindly and separately from a neurological assessment of hard and soft signs. RESULTS: Obstetric complications (OCs) were significantly increased in patients but not in siblings compared to their respective neonatal control groups. Neurological abnormalities were related to OCs in siblings but not in patients. Neurological abnormalities in patients were negatively related to reduced neonatal head circumference. CONCLUSION: Early somatic trauma may increase the probability of neurological abnormality in individuals who are genetically 'at risk'.
OBJECTIVE: Previous findings of increased neurological abnormalities in schizophrenicpatients and their non-psychotic siblings raise the question of possible causes. The purpose of the present study was to examine the role of perinatal trauma in the aetiology of neurological abnormality. METHOD: Obstetric information obtained from hospital records for 55 schizophrenicpatients and 19 non-psychotic siblings was scored blindly and separately from a neurological assessment of hard and soft signs. RESULTS: Obstetric complications (OCs) were significantly increased in patients but not in siblings compared to their respective neonatal control groups. Neurological abnormalities were related to OCs in siblings but not in patients. Neurological abnormalities in patients were negatively related to reduced neonatal head circumference. CONCLUSION: Early somatic trauma may increase the probability of neurological abnormality in individuals who are genetically 'at risk'.
Authors: Christina G S Palmer; Joni A Turunen; Janet S Sinsheimer; Sonia Minassian; Tiina Paunio; Jouko Lönnqvist; Leena Peltonen; J Arthur Woodward Journal: Am J Hum Genet Date: 2002-11-18 Impact factor: 11.025
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