| Literature DB >> 10705727 |
K Shimizu1, M Fukuda, R Kondo, K Sakai.
Abstract
The methanol extract of heartwood of Artocarpus incisus showed potent 5 alpha-reductase inhibitory activity. We investigated the 5 alpha-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 microM) and artocarpin (IC50 = 85 microM) showed more potent inhibitory effects than did alpha-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5 alpha-reductase inhibitory effects.Entities:
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Year: 2000 PMID： 10705727 DOI： 10.1055/s-2000-11114
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352