| Literature DB >> 10705295 |
S Lebel-Binay1, A Berger, F Zinzindohoué, P Cugnenc, N Thiounn, W H Fridman, F Pagès.
Abstract
IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.Entities:
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Year: 2000 PMID： 10705295
Source DB: PubMed Journal: Eur Cytokine Netw ISSN： 1148-5493 Impact factor: 2.737