| Literature DB >> 10704870 |
M Kanai-Azuma1, J S Mattick, K Kaibuchi, S A Wood.
Abstract
The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam de-ubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina.Entities:
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Year: 2000 PMID： 10704870 DOI： 10.1016/s0925-4773(99)00294-4
Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882