| Literature DB >> 10704839 |
M R Bendel-Stenzel1, M Gomperts, R Anderson, J Heasman, C Wylie.
Abstract
Primordial germ cells (PGCs) are the founder cells of the gametes. In mammals, PGCs migrate from the hindgut to the genital ridges, where they coalesce with each other and with somatic cells to form the primary sex cords. We show here that, in both sexes, PGCs express P- and E-cadherins during and after migration, and N-cadherin at post-migratory stages. E-Cadherin is not expressed by PGCs whilst in the hindgut, but is upregulated as they leave. Blocking antibodies against E-, but not P-cadherin cause defective PGC-PGC coalescence, and in some cases, ectopic PGCs.Entities:
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Year: 2000 PMID： 10704839 DOI： 10.1016/s0925-4773(99)00287-7
Source DB: PubMed Journal: Mech Dev ISSN： 0925-4773 Impact factor: 1.882