Literature DB >> 10704811

Polyamidoamine Starburst dendrimers as solubility enhancers.

O M Milhem1, C Myles, N B McKeown, D Attwood, A D'Emanuele.   

Abstract

The solubility of the hydrophobic drug ibuprofen has been compared in an aqueous solution of polyamidoamine (PAMAM) G4 dendrimer and sodium dodecyl sulphate (SDS). The PAMAM G4 dendrimer solution significantly enhanced the solubility of ibuprofen compared to 2% SDS solution. It was found that the solubility of ibuprofen in dendrimer solution was directly proportional to dendrimer concentration and inversely proportional to temperature. The influence of dendrimer solution pH on the solubility enhancement of ibuprofen suggests that it involves an electrostatic interaction between the carboxyl group of the ibuprofen molecule and the amine groups of the dendrimer molecule.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10704811     DOI： 10.1016/s0378-5173(99)00463-9

Source DB:  PubMed          Journal:  Int J Pharm        ISSN： 0378-5173            Impact factor:   5.875


  21 in total

1.  G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity.

Authors:  Deborah S Goldberg; Nirmalkumar Vijayalakshmi; Peter W Swaan; Hamidreza Ghandehari
Journal:  J Control Release       Date:  2010-11-27       Impact factor: 9.776

2.  Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient.

Authors:  Abhay Asthana; Abhay Singh Chauhan; Prakash Vamanrao Diwan; Narendra Kumar Jain
Journal:  AAPS PharmSciTech       Date:  2005-10-27       Impact factor: 3.246

3.  PAMAM-camptothecin conjugate inhibits proliferation and induces nuclear fragmentation in colorectal carcinoma cells.

Authors:  Giridhar Thiagarajan; Abhijit Ray; Alexander Malugin; Hamidreza Ghandehari
Journal:  Pharm Res       Date:  2010-06-15       Impact factor: 4.200

4.  Molecular simulation study of PAMAM dendrimer composite membranes.

Authors:  Sepideh Amjad-Iranagh; Karim Golzar; Hamid Modarress
Journal:  J Mol Model       Date:  2014-02-11       Impact factor: 1.810

Review 5.  Bioengineering strategies for designing targeted cancer therapies.

Authors:  Angela A Alexander-Bryant; Wendy S Vanden Berg-Foels; Xuejun Wen
Journal:  Adv Cancer Res       Date:  2013       Impact factor: 6.242

Review 6.  Recent perspectives in ocular drug delivery.

Authors:  Ripal Gaudana; J Jwala; Sai H S Boddu; Ashim K Mitra
Journal:  Pharm Res       Date:  2008-08-29       Impact factor: 4.200

Review 7.  Nanoplatforms for constructing new approaches to cancer treatment, imaging, and drug delivery: what should be the policy?

Authors:  Babak Kateb; Katherine Chiu; Keith L Black; Vicky Yamamoto; Bhavraj Khalsa; Julia Y Ljubimova; Hui Ding; Rameshwar Patil; Jose Antonio Portilla-Arias; Mike Modo; David F Moore; Keyvan Farahani; Michael S Okun; Neal Prakash; Josh Neman; Daniel Ahdoot; Warren Grundfest; Shouleh Nikzad; John D Heiss
Journal:  Neuroimage       Date:  2010-02-10       Impact factor: 7.400

8.  DNA compaction induced by a cationic polymer or surfactant impact gene expression and DNA degradation.

Authors:  Marie-Louise Ainalem; Andrew Bartles; Joscha Muck; Rita S Dias; Anna M Carnerup; Daniele Zink; Tommy Nylander
Journal:  PLoS One       Date:  2014-03-26       Impact factor: 3.240

9.  Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates.

Authors:  Suneela Pyreddy; Pandurangan Dinesh Kumar; Palanirajan Vijayaraj Kumar
Journal:  Int J Pharm Investig       Date:  2014-01

10.  Solubility of aceclofenac in polyamidoamine dendrimer solutions.

Authors:  Jaydeep Patel; Kevin Garala; Biswajit Basu; Mihir Raval; Abhay Dharamsi
Journal:  Int J Pharm Investig       Date:  2011-07
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.