Literature DB >> 10704764

Expression of growth hormone receptor in the human brain.

J R Castro1, J A Costoya, R Gallego, A Prieto, V M Arce, R Señarís.   

Abstract

This study was designed to investigate the presence of growth hormone receptor (GHR) expression in the human brain tissue, both normal and tumoral, as well as in the human glioblastoma cell line U87MG. Reverse transcription-polymerase chain reaction revealed the presence of GHR mRNA in all brain samples investigated and in U87MG cells. GHR immunoreactivity was also detected in this cell line using both immunocytochemistry and western blotting. All together, our data demonstrate the existence of GHR expression within the central nervous system (CNS), thus supporting a possible role for GH in the CNS physiology.

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Year:  2000        PMID： 10704764     DOI： 10.1016/s0304-3940(00)00830-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

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7.  Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma.

Authors:  Maïté Verreault; Irma Segoviano Vilchis; Shai Rosenberg; Nolwenn Lemaire; Charlotte Schmitt; Jérémy Guehennec; Louis Royer-Perron; Jean-Léon Thomas; TuKiet T Lam; Florent Dingli; Damarys Loew; François Ducray; Sophie Paris; Catherine Carpentier; Yannick Marie; Florence Laigle-Donadey; Audrey Rousseau; Natascha Pigat; Florence Boutillon; Franck Bielle; Karima Mokhtari; Stuart J Frank; Aurélien de Reyniès; Khê Hoang-Xuan; Marc Sanson; Vincent Goffin; Ahmed Idbaih
Journal:  Clin Transl Med       Date:  2022-07
  7 in total

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