| Literature DB >> 10704684 |
R Steinberg1, E Freud, M Zer, I Ziperman, Y Goshen, S Ash, J Stein, R Zaizov, S Avigad.
Abstract
We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor.Entities:
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Year: 2000 PMID： 10704684 DOI： 10.1016/s0165-4608(99)00165-x
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608