Literature DB >> 107032

Centrally administered neurotensin: activity in the Julou-Courvoisier muscle relaxation test in mice.

A J Osbahr, C B Nemeroff, P J Manberg, A J Prange.   

Abstract

Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects on NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.

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Year:  1979        PMID： 107032     DOI： 10.1016/0014-2999(79)90090-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.

Authors:  Lauren M Slosky; Yushi Bai; Krisztian Toth; Caroline Ray; Lauren K Rochelle; Alexandra Badea; Rahul Chandrasekhar; Vladimir M Pogorelov; Dennis M Abraham; Namratha Atluri; Satyamaheshwar Peddibhotla; Michael P Hedrick; Paul Hershberger; Patrick Maloney; Hong Yuan; Zibo Li; William C Wetsel; Anthony B Pinkerton; Lawrence S Barak; Marc G Caron
Journal:  Cell       Date:  2020-05-28       Impact factor: 41.582

2.  Possible neuronal mechanisms involved in neurotensin-induced catalepsy in mice.

Authors:  K Shibata; K Yamada; T Furukawa
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

3.  Behavioral analysis of the effect of neurotensin injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat.

Authors:  M Cador; A E Kelley; M Le Moal; L Stinus
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

4.  Association between neurotensin receptor 1 gene polymorphisms and alcohol dependence in a male Han Chinese population.

Authors:  Hui Ma; Yinglin Huang; Bo Zhang; Yuan Wang; Hong Zhao; Hong Du; Zhengtu Cong; Jingying Li; Gang Zhu
Journal:  J Mol Neurosci       Date:  2013-06-08       Impact factor: 3.444

5.  Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine.

Authors:  C B Nemeroff; A J Osbahr; P J Manberg; G N Ervin; A J Prange
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

6.  NT79: A novel neurotensin analog with selective behavioral effects.

Authors:  Mona Boules; Yanqi Liang; Siobhan Briody; Tomofumi Miura; Irfan Fauq; Alfredo Oliveros; Mina Wilson; Shaheen Khaniyev; Katrina Williams; Zhimin Li; Yanfei Qi; Michael Katovich; Elliott Richelson
Journal:  Brain Res       Date:  2009-10-27       Impact factor: 3.252
  6 in total

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