| Literature DB >> 10703061 |
N Asano1, M Nishida, M Miyauchi, K Ikeda, M Yamamoto, H Kizu, Y Kameda, A A Watson, R J Nash, G W Fleet.
Abstract
Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM).Entities:
Mesh：
Substances：
Year: 2000 PMID： 10703061 DOI： 10.1016/s0031-9422(99)00555-5
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072